Vascular calcification and bone disease: the calcification paradox

V Persy, P D'Haese - Trends in molecular medicine, 2009 - cell.com
Vascular calcification or ectopic mineralization in blood vessels is an active, cell-regulated
process, increasingly recognized as a general cardiovascular risk factor. Remarkably …

Mechanisms and clinical consequences of vascular calcification

D Zhu, NCW Mackenzie, C Farquharson… - Frontiers in …, 2012 - frontiersin.org
Vascular calcification has severe clinical consequences and is considered an accurate
predictor of future adverse cardiovascular events, including myocardial infarction and stroke …

Vascular calcification and osteoporosis—from clinical observation towards molecular understanding

LC Hofbauer, CC Brueck, CM Shanahan… - Osteoporosis …, 2007 - Springer
Patients with osteoporosis frequently suffer from vascular calcification, which was shown to
predict both cardiovascular morbidity/mortality and osteoporotic fractures. Various common …

Vascular calcification—new insights into its mechanism

SJ Lee, IK Lee, JH Jeon - International journal of molecular sciences, 2020 - mdpi.com
Vascular calcification (VC), which is categorized by intimal and medial calcification,
depending on the site (s) involved within the vessel, is closely related to cardiovascular …

A novel role of cellular interactions in vascular calcification

ASA Bardeesi, J Gao, K Zhang, S Yu, M Wei… - Journal of translational …, 2017 - Springer
A series of clinical trials have confirmed the correlation between vascular calcification (VC)
and cardiovascular events and mortality. However, current treatments have little effects on …

Vascular calcification: pathobiological mechanisms and clinical implications

RC Johnson, JA Leopold, J Loscalzo - Circulation research, 2006 - Am Heart Assoc
Once thought to result from passive precipitation of calcium and phosphate, it now appears
that vascular calcification is a consequence of tightly regulated processes that culminate in …

Vascular calcification: an update on mechanisms and challenges in treatment

M Wu, C Rementer, CM Giachelli - Calcified tissue international, 2013 - Springer
Vascular calcification is highly associated with cardiovascular disease mortality, particularly
in high-risk patients with diabetes and chronic kidney diseases (CKD). In blood vessels …

Calcifying vascular smooth muscle cells and osteoblasts: independent cell types exhibiting extracellular matrix and biomineralization-related mimicries

RDAM Alves, M Eijken, J van de Peppel… - BMC genomics, 2014 - Springer
Background Ectopic vascular calcifications represent a major clinical problem associated
with cardiovascular disease and mortality. However, the mechanisms underlying …

Arterial calcification and bone physiology: role of the bone–vascular axis

B Thompson, DA Towler - Nature Reviews Endocrinology, 2012 - nature.com
Bone never forms without vascular interactions. This simple statement of fact does not
adequately reflect the physiological and pharmacological implications of the relationship …

Molecular, endocrine, and genetic mechanisms of arterial calcification

TM Doherty, LA Fitzpatrick, D Inoue, JH Qiao… - Endocrine …, 2004 - academic.oup.com
Pathologists have recognized arterial calcification for over a century. Recent years have
witnessed a strong resurgence of interest in atherosclerotic plaque calcification because it …