Inhibiting the NLRP3 inflammasome mediates inflammation in an extensive number of
preclinical models. As excitement in this field has grown, several companies have recently …

Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …

The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …

NLRP3 inflammasome is a multiprotein complex involved in host immune response─ which
exerts various biological effects by mediating the maturation and secretion of IL-1β and IL …

Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …

The NLRP3 inflammasome is a cytoplasmic multiprotein complex, the assembly of which
can be initiated in response to various exogenous or endogenous danger signals …

Inflammasomes are cytosolic pattern recognition receptors that recognize pathogen-
associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) …

Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …

NLRP3 (Nod-like receptor protein 3) belongs to the NOD-like receptor family, which is
activated by pathogen and damage-associated signals to form a multimeric protein complex …

The inflammasome is a molecular platform formed by activation of an innate immune pattern
recognition receptor seed, such as NLRP3. Once activated, NLRP3 recruits the adapter ASC …