Inflammasomes are multiprotein signaling platforms in the cytosol that senses exogenous
and endogenous danger signals and respond with the maturation and secretion of IL-1β and …

The NLRP3 inflammasome is a critical component of innate immunity that senses diverse
pathogen-and host-derived molecules. However, its aberrant activation has been associated …

Highlights•NLRP1 is a sensor of diverse pathogen-encoded activities.•'Functional
degradation'provides a mechanism for NLRP1 activation.•New insights into NLRP1 have …

Abstract The NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is
an immunological sensor that detects a wide range of microbial-and host-derived signals …

Inflammasomes are multiprotein complexes that serve as a platform for caspase-1 activation
and interleukin-1β (IL-1β) maturation as well as pyroptosis. Though a number of …

A critical component of innate immune response to infection and tissue damage is the
NACHT, LRR, and PYD domains–containing protein 3 (NLRP3) inflammasome, and this …

In response to inflammatory stimuli, immune cells reconfigure their metabolism and
bioenergetics to generate energy and substrates for cell survival and to launch immune …

Inflammation driven by the NLRP3 inflammasome is coordinated through multiple signaling
pathways and is regulated by subcellular organelles. Here, we tested the hypothesis that …

The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many
contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing" signal I" …

Inflammasomes are supramolecular protein complexes implicated in the detection of
pathogens or danger-associated molecules and are responsible for mounting the first line of …