[HTML][HTML] Reaching the end-game for GWAS: machine learning approaches for the prioritization of complex disease loci
Genome-wide association studies (GWAS) have revealed thousands of genetic loci that
underpin the complex biology of many human traits. However, the strength of GWAS–the …
underpin the complex biology of many human traits. However, the strength of GWAS–the …
Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
Genome-wide association studies (GWASs) have identified many variants associated with
complex traits, but identifying the causal gene (s) is a major challenge. In the present study …
complex traits, but identifying the causal gene (s) is a major challenge. In the present study …
[图书][B] Genome-wide association studies and genomic prediction
C Gondro, J Van der Werf, B Hayes - 2013 - Springer
Genome-wide association studies (GWAS) have rapidly spread across the globe over the
last few years becoming the de facto approach to identify candidate regions associated with …
last few years becoming the de facto approach to identify candidate regions associated with …
Genome-wide association studies: hypothesis-“free” or “engaged”?
GD Kitsios, E Zintzaras - Translational Research, 2009 - Elsevier
The advent of the first wave of genome-wide association studies (GWAS) provided a new
conceptual framework in the search for variants underlying common disorders: a massive …
conceptual framework in the search for variants underlying common disorders: a massive …
[PDF][PDF] The post-GWAS era: from association to function
MD Gallagher, AS Chen-Plotkin - The American Journal of Human …, 2018 - cell.com
During the past 12 years, genome-wide association studies (GWASs) have uncovered
thousands of genetic variants that influence risk for complex human traits and diseases. Yet …
thousands of genetic variants that influence risk for complex human traits and diseases. Yet …
Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
[PDF][PDF] Deciphering the emerging complexities of molecular mechanisms at GWAS loci
ME Cannon, KL Mohlke - The American Journal of Human Genetics, 2018 - cell.com
Genome-wide association studies (GWASs) have identified thousands of loci associated
with hundreds of complex diseases and traits, and progress is being made toward …
with hundreds of complex diseases and traits, and progress is being made toward …
Guidelines for genome-wide association studies
Genome-wide association studies (GWAS) have revolutionized human genetics. They have
led to the identification of thousands of loci that affect both normal variation and susceptibility …
led to the identification of thousands of loci that affect both normal variation and susceptibility …
Using gene expression to investigate the genetic basis of complex disorders
AC Nica, ET Dermitzakis - Human molecular genetics, 2008 - academic.oup.com
The identification of complex disease susceptibility loci through genome-wide association
studies (GWAS) has recently become possible and is now a method of choice for …
studies (GWAS) has recently become possible and is now a method of choice for …