Immunosenescence and Inflammaging in COVID-19

F Asghari, A Asghary, N Majidi Zolbanin, F Faraji… - Viral …, 2023 - liebertpub.com
Despite knowledge gaps in understanding the full spectrum of the hyperinflammatory phase
caused by SARS-CoV-2, according to the World Health Organization (WHO), COVID-19 is …

Remodeling of the immune response with aging: immunosenescence and its potential impact on COVID-19 immune response

LL Cunha, SF Perazzio, J Azzi, P Cravedi… - Frontiers in …, 2020 - frontiersin.org
Elderly individuals are the most susceptible to an aggressive form of coronavirus disease
(COVID-19), caused by SARS-CoV-2. The remodeling of immune response that is observed …

Aging, inflammaging and immunosenescence as risk factors of severe COVID-19

AM Tizazu, HM Mengist, G Demeke - Immunity & Ageing, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …

Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes

J Sabbatinelli, G Matacchione, A Giuliani… - Mechanisms of Ageing …, 2022 - Elsevier
The COVID-19 pandemic caused by SARS-CoV-2 infection has been of unprecedented
clinical and socio-economic worldwide relevance. The case fatality rate for COVID-19 grows …

How immunosenescence and inflammaging may contribute to hyperinflammatory syndrome in COVID-19

L Müller, S Di Benedetto - International journal of molecular sciences, 2021 - mdpi.com
Aging is characterized by the dynamic remodeling of the immune system designated
“immunosenescence,” and is associated with altered hematopoiesis, thymic involution, and …

Immunopathology and immunosenescence, the immunological key words of severe COVID-19. Is there a role for stem cell transplantation?

ME Ligotti, F Pojero, G Accardi, A Aiello… - Frontiers in Cell and …, 2021 - frontiersin.org
The outcomes of Coronavirus disease-2019 (COVID-19) vary depending on the age, health
status and sex of an individual, ranging from asymptomatic to lethal. From an immunologic …

I mmunosenescence and inflammaging: risk factors of severe COVID-19 in older people

AJ Pietrobon, FME Teixeira, MN Sato - Frontiers in immunology, 2020 - frontiersin.org
Old individuals are more susceptible to various infections due to immunological changes
that occur during the aging process. These changes named collectively as …

[HTML][HTML] Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19

L Omarjee, F Perrot, O Meilhac, G Mahe… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-
19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to …

Patho-physiology of aging and immune-senescence: possible correlates with comorbidity and mortality in middle-aged and old COVID-19 patients

S Farheen, S Agrawal, S Zubair, A Agrawal… - Frontiers in …, 2021 - frontiersin.org
During the last 2 years, the entire world has been severely devastated by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic (COVID-19) as it resulted in …

Immunesenescence: a predisposing risk factor for the development of COVID-19?

J Hazeldine, JM Lord - Frontiers in immunology, 2020 - frontiersin.org
Bearing a strong resemblance to the phenotypic and functional remodeling of the immune
system that occurs during aging (termed immunesenescence), the immune response to …