Cancer is a multifactorial heterogeneous disease characterized by multistage nature of
pathogenesis. Over the past two or three decades, we have witnessed an enormous …

Chemoprevention refers to the use of defined non-toxic chemical regimens to inhibit, reverse
or retard the process of multi-stage carcinogenesis that involves multiple signal transduction …

Cancer statistics from the American Cancer Society and other sources are a stark reminder
of our failure to combat this deadly disease. Chemoprevention entails the use of specific …

The transcription factor nuclear factor kappa B (NFκB) is found in nearly all animal cell types.
It is involved in cellular responses to stimuli such as stress, cytokines, free radicals …

Nrf2 (nuclear factor erythroid 2-related factor 2) and NF-κB (nuclear factor–kappa B)
signaling pathways play a central role in suppressing or inducing inflammation and …

Natural phytochemicals derived from dietary sources or medicinal plants have gained
significant recognition in the potential management of several human clinical conditions …

The inhibition of carcinogenesis by chemopreventive agents has been demonstrated in
many tumorigenesis animal models. The chemopreventive mechanisms of those …

Oxidative stress has been implicated in various pathological conditions including cancer.
However, the human body has an intrinsic ability to fight against oxidative stress. A wide …

Reactive oxygen species, produced by oxidative stress, are implicated in the initiation,
promotion, and malignant conversion of carcinogenesis through activation/suppression of …

Oxidative stress occurs when cellular reactive oxygen species levels exceed the self-
antioxidant capacity of the body. Oxidative stress induces many pathological changes …