Chemoprevention refers to the use of defined non-toxic chemical regimens to inhibit, reverse or retard the process of multi-stage carcinogenesis that involves multiple signal transduction …
A Gopalakrishnan, ANT Kong - Food and Chemical Toxicology, 2008 - Elsevier
Cancer statistics from the American Cancer Society and other sources are a stark reminder of our failure to combat this deadly disease. Chemoprevention entails the use of specific …
S Luqman, JM Pezzuto - Phytotherapy Research, 2010 - Wiley Online Library
The transcription factor nuclear factor kappa B (NFκB) is found in nearly all animal cell types. It is involved in cellular responses to stimuli such as stress, cytokines, free radicals …
V Krajka-Kuźniak, W Baer-Dubowska - International Journal of Molecular …, 2021 - mdpi.com
Nrf2 (nuclear factor erythroid 2-related factor 2) and NF-κB (nuclear factor–kappa B) signaling pathways play a central role in suppressing or inducing inflammation and …
Natural phytochemicals derived from dietary sources or medicinal plants have gained significant recognition in the potential management of several human clinical conditions …
G Shen, WS Jeong, R Hu, ANT Kong - Antioxidants & redox …, 2005 - liebertpub.com
The inhibition of carcinogenesis by chemopreventive agents has been demonstrated in many tumorigenesis animal models. The chemopreventive mechanisms of those …
YJ Surh, JK Kundu, HK Na, JS Lee - The Journal of nutrition, 2005 - Elsevier
Oxidative stress has been implicated in various pathological conditions including cancer. However, the human body has an intrinsic ability to fight against oxidative stress. A wide …
I Bellezza, AL Mierla, A Minelli - Cancers, 2010 - mdpi.com
Reactive oxygen species, produced by oxidative stress, are implicated in the initiation, promotion, and malignant conversion of carcinogenesis through activation/suppression of …
W Li, Y Guo, C Zhang, R Wu, AY Yang… - Chemical research in …, 2016 - ACS Publications
Oxidative stress occurs when cellular reactive oxygen species levels exceed the self- antioxidant capacity of the body. Oxidative stress induces many pathological changes …