Development of the metanephric kidney is strongly dependent on complex signaling
pathways and cell–cell communication between at least four major progenitor cell …

The postnatal kidney is predominantly composed of nephron epithelia with the interstitial
components representing a small proportion of the final organ, except in the diseased state …

Recent advances in the generation of kidney organoids and the culture of primary nephron
progenitors from mouse and human have been based on knowledge of the molecular basis …

There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …

Genetically engineered mice have provided much information about gene function in the
field of developmental biology. Recently, conditional gene targeting using the Cre/loxP …

Background: Kidney diseases are worldwide public health problems with a high cost and
increasing incidence. By revealing the genetic and cellular mechanism behind mammalian …

The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …

Nephron formation continues throughout kidney morphogenesis in both mice and humans.
Lineage tracing studies in mice identified a self‐renewing Six2‐expressing nephron …

Summary Recapitulating three-dimensional (3D) structures of complex organs, such as the
kidney, from pluripotent stem cells (PSCs) is a major challenge. Here, we define the …

The kidney is a model developmental system for understanding mesodermal patterning and
organogenesis, a process that requires regional specification along multiple body axes, the …