The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) helicase NSP13 plays
a conserved role in the replication of coronaviruses and has been identified as an ideal …

The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health challenge …

The raging COVID-19 pandemic caused by SARS-CoV-2 has infected tens of millions of
people and killed several hundred thousand patients worldwide. Currently, there are no …

SARS-CoV-2 infection is still spreading worldwide, and new antiviral therapies are an urgent
need to complement the approved vaccine preparations. SARS-CoV-2 nps13 helicase is a …

For RNA viruses, RNA helicases have long been recognized to play critical roles during
virus replication cycles, facilitating proper folding and replication of viral RNAs, therefore …

Replication of the 30-kilobase genome of SARS-CoV-2, responsible for COVID-19, is a key
step in the coronavirus life cycle that requires a set of virally encoded nonstructural proteins …

The SARS-CoV-2 non-structural protein 13 (nsp13) helicase is an essential enzyme for viral
replication and has been identified as an attractive target for the development of new …

To date, effective therapeutic treatments that confer strong attenuation against coronaviruses
(CoVs) remain elusive. Among potential drug targets, the helicase of CoVs is attractive due …

SARS-CoV-2 non-structural protein 13 (nsp13) is a highly conserved helicase and RNA 5′-
triphosphatase. It uses the energy derived from the hydrolysis of nucleoside triphosphates …

Abstract The SARS-CoV-2 helicase Nsp13 is a promising target for developing anti-COVID
drugs. In the present study, we have identified potential natural product inhibitors of SARS …