In spite of recent efforts to eradicate malaria in the world, this parasitic disease is still
considered a major public health problem, with a total of 216 million cases of malaria and …

The parasitic disease malaria places almost half of the world's population at risk of infection
and is responsible for more than 400,000 deaths each year. The first-line treatment …

Amongst several communicable diseases (CDs), malaria is one of the deadliest parasitic
disease all over the world, particularly in African and Asian countries. To curb this menace …

Background The widespread emergence of anti-malarial drug resistance has necessitated
the discovery of novel anti-malarial drug candidates. In this study, chloroquine derivatives …

Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs,
chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for …

Based on medicinal chemistry tools, new compounds for malaria treatment were designed.
The scaffolds of the drugs used to treat malaria, such as chloroquine, primaquine …

Chloroquine (CQ) is a cost effective antimalarial drug with a relatively good safety profile (or
therapeutic index). However, CQ is no longer used alone to treat patients with Plasmodium …

Despite recent progress in the fight against malaria, the emergence and spread of drug-
resistant parasites remains a serious obstacle to the treatment of infections. We recently …

This is a general review of currently available antimalarial drugs, these compounds are
gathered according with its chemical structure and the biological targets. A great number of …

We have previously shown that a “reversed chloroquine (RCQ)” molecule, composed of a
chloroquine-like moiety and a resistance reversal-like moiety, can overcome chloroquine …