Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear …

DL Walker, M Davis - Learning & Memory, 2008 - learnmem.cshlp.org
Within the amygdala, most N-methyl-D-aspartic acid (NMDA) receptors consist of NR1
subunits in combination with either NR2A or NR2B subunits. Because the particular subunit …

Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala

F Sotres-Bayon, DEA Bush, JE LeDoux - Neuropsychopharmacology, 2007 - nature.com
N-methyl-D-aspartate receptors (NMDARs) contribute to synaptic plasticity underlying
learning in a variety of brain systems. Fear extinction, which involves learning to suppress …

Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory

XH Zhang, F Liu, Q Chen, CL Zhang, M Zhuo… - …, 2008 - Elsevier
It is known that N-methyl-d-aspartate (NMDA) receptor in the basolateral nucleus of
amygdala (BLA) is essential for fear memory formation. NMDA NR2B and NR2A subtype …

Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning

SM Rodrigues, GE Schafe, JE LeDoux - Journal of neuroscience, 2001 - Soc Neuroscience
The lateral nucleus of the amygdala (LA) is an essential component of the neural circuitry
underlying Pavlovian fear conditioning. Although blockade of NMDA receptors in LA and …

NMDA currents and receptor protein are downregulated in the amygdala during maintenance of fear memory

F Zinebi, J Xie, J Liu, RT Russell… - Journal of …, 2003 - Soc Neuroscience
The amygdala plays a critical role in fear conditioning, a model of emotional learning and
cue-induced anxiety. In the lateral amygdala, fear conditioning is associated with an …

NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala

KA Goosens, S Maren - European Journal of Neuroscience, 2004 - Wiley Online Library
We examined the contribution of N‐methyl‐d‐aspartate (NMDA) receptors (NMDARs) to the
acquisition and expression of amygdaloid plasticity and Pavlovian fear conditioning using …

Fear memory impairing effects of systemic treatment with the NMDA NR2B subunit antagonist, Ro 25-6981, in mice: attenuation with ageing

P Mathur, C Graybeal, M Feyder, MI Davis… - Pharmacology …, 2009 - Elsevier
N-methyl-d-aspartate receptors (NMDARs) are mediators of synaptic plasticity and learning
and are implicated in the pathophysiology of neuropsychiatric disease and age-related …

Injections of the NMDA receptor antagonist aminophosphonopentanoic acid into the lateral nucleus of the amygdala block the expression of fear-potentiated startle …

M Fendt - Journal of Neuroscience, 2001 - Soc Neuroscience
NMDA receptors within the amygdala play an important role in the acquisition and
expression of conditioned fear. Because amygdaloid injections of NMDA receptor …

Distinct populations of NMDA receptors at subcortical and cortical inputs to principal cells of the lateral amygdala

MG Weisskopf, JE LeDoux - Journal of neurophysiology, 1999 - journals.physiology.org
Distinct populations of NMDA receptors at subcortical and cortical inputs to principal cells of
the lateral amygdala. Fear conditioning involves the transmission of sensory stimuli to the …

Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution

F Sotres-Bayon, L Diaz-Mataix, DEA Bush… - Cerebral …, 2009 - academic.oup.com
Fear extinction, which involves learning to suppress the expression of previously learned
fear, requires N-methyl-D-aspartate receptors (NMDARs) and is mediated by the amygdala …