Turnover and exchange of nucleosomal histones and their variants, a process long believed
to be static in post-replicative cells, remains largely unexplored in brain. Here, we describe a …

Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Plasticity in gene expression is achieved by a complex array of molecular mechanisms by
which intracellular signaling pathways directly govern transcriptional regulation. In addition …

Neural stem cells generate distinct cell types for tissue formation and cell replacement
during development and throughout adulthood. Neural development and plasticity are …

Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …

Histone Modifications: Insights into Their Influence on Gene Expression: Cell Skip to Main
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Nucleosomes composed of histone octamer and DNA are the basic structural unit in the
eukaryote chromosome. Under the stimulation of various factors, histones will undergo …

BACKGROUND: The development of the nervous system is a highly organized process
involving the precise and coordinated timing of many complex events. These events require …

Nucleosome dynamics and properties are central to all forms of genomic activities. Among
the core histones, H3 variants play a pivotal role in modulating nucleosome structure and …

The development and function of neurons require the regulated expression of large
numbers of very specific gene sets. Epigenetic modifications of both DNA and histone …