Epigenetic changes can influence a variety of cellular processes from regulation of gene
transcription to proper chromosome segregation. The molecular activities that dictate the …

The tumour suppressor gene (Rb1) is necessary for the maintenance of telomere integrity in
osteoblastic cells. We now show that the compaction of telomeric chromatin and the …

Progression of cells through the cell cycle is central to normal cell proliferation, and
checkpoints that regulate this cycle are targets of tumorigenic mutations. One of these …

The retinoblastoma protein, Rb, is encoded by a classic tumor suppressor gene that is
mutated in a large variety of tumors. Extensive studies have suggested that Rb functions as …

Here, we show a role for the RB1 family proteins in directing full heterochromatin formation.
Mouse embryonic fibroblasts that are triply deficient for RB1 (retinoblastoma 1), RBL1 …

The canonical model of RB-mediated tumour suppression developed over the past 30 years
is based on the regulation of E2F transcription factors to restrict cell cycle progression …

Loss of cell-cycle control is a hallmark of neoplastic cells. One regulator of the critical G1 to S-
phase transition in the cell cycle is the retinoblastoma tumour suppressor protein Rb, which …

RB, a well known tumour suppressor that functions in the control of cell cycle progression
and proliferation, has recently been shown to have additional functions in the maintenance …

The retinoblastoma (RB) protein exerts its tumour-suppressor function by repressing the
transcription of cellular genes required for DNA replication and cell division. Recent …

The retinoblastoma protein (pRb) has been proposed to regulate cell cycle progression in
part through its ability to interact with enzymes that modify histone tails and create a …