The development of tissue engineering strategies for treatment of large bone defects has
become increasingly relevant, given the growing demand for bone substitutes. Native bone …

Vascularization remains one of the most important challenges that must be overcome for
tissue engineering to be consistently implemented for reconstruction of large volume bone …

Vascularization has a pivotal role in engineering successful tissue constructs. However, it
remains a major hurdle of bone tissue engineering, especially in clinical applications for the …

Survival of functional tissue constructs of clinically relevant size depends on the formation of
an organized and uniformly distributed network of blood vessels and capillaries. The lack of …

Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

Vascularization of large bone grafts is one of the main challenges of bone tissue
engineering (BTE), and has held back the clinical translation of engineered bone constructs …

Tissue engineering uses various approaches to restore bone loss and heal critical-size
defects resulting from trauma, infection, tumor resection or other musculoskeletal diseases …

Bone is one of the most vascular network-rich tissues in the body and the vascular system is
essential for the development, homeostasis, and regeneration of bone. When segmental …

There is a profound need for orthopaedic grafting strategies due to various trauma and
musculoskeletal diseases. Tissue engineering offers a promising avenue to develop viable …

Biomaterial based reconstruction is still the most commonly employed method of small bone
defect reconstruction. Bone tissue-engineered techniques are improving, and adjuncts such …