The paracellular claudin channel of the thick ascending limb (TAL) of Henle is critical for
Ca++ reabsorption in the kidney. Genome‐wide association studies (GWASs) have …

Pathologic dysregulation of extracellular calcium metabolism is difficult to correct. The
extracellular Ca++-sensing receptor (CaSR), a G protein–coupled receptor that regulates …

The renal proximal tubule (PT) is responsible for the reabsorption of approximately 65% of
filtered calcium, primarily via a paracellular pathway. However, which protein (s) contribute …

Claudins are discovered to be key players in renal epithelial physiology. They are involved
in developmental, physiological, and pathophysiological differentiation. In the glomerular …

Tight junctions play a key role in mediating paracellular ion reabsorption in the kidney.
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a human …

Kidney stones are a prevalent clinical condition imposing a large economic burden on the
healthcare system. Hypercalciuria remains the major risk factor for development of a Ca2+ …

Claudins are tight junction proteins that play a key selectivity role in the paracellular
conductance of ions. Numerous studies of claudin function have been carried out using the …

The major risk factor for kidney stone disease is idiopathic hypercalciuria. Recent evidence
implicates a role for defective calcium reabsorption in the renal proximal tubule. We …

Calcium (Ca2+) homeostasis is maintained through coordination between intestinal
absorption, renal reabsorption, and bone remodeling. Intestinal and renal (re) absorption …

Claudins are tight junction integral membrane proteins that are key regulators of the
paracellular pathway. Defects in claudin-16 (CLDN16) and CLDN19 function result in the …