Mapping open chromatin regions has emerged as a widely used tool for identifying active
regulatory elements in eukaryotes. However, existing approaches, limited by reliance on …

Comprehensive characterization of cellular heterogeneity and the underlying regulatory
landscapes of tissues and organs requires a highly robust and scalable method to acquire …

Transcriptional activation throughout the eukaryotic lineage has been tightly linked with
disruption of nucleosome organization at promoters, enhancers, silencers, insulators and …

Single-cell ATAC sequencing (scATAC-seq) is a powerful and increasingly popular
technique to explore the regulatory landscape of heterogeneous cellular populations …

Cell-to-cell variation is a universal feature of life that affects a wide range of biological
phenomena, from developmental plasticity, to tumour heterogeneity. Although recent …

Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …

Joint profiling of chromatin accessibility and gene expression from the same single cell
provides critical information about cell types in a tissue and cell states during a dynamic …

Here we develop a high-throughput single-cell ATAC-seq (assay for transposition of
accessible chromatin) method to measure physical access to DNA in whole cells. Our …

Cellular function in tissue is dependent on the local environment, requiring new methods for
spatial mapping of biomolecules and cells in the tissue context. The emergence of spatial …

High-throughput single-cell epigenomic assays can resolve cell type heterogeneity in
complex tissues, however, spatial orientation is lost. Here, we present single-cell …