Chromatin profiling provides a versatile means to investigate functional genomic elements
and their regulation. However, current methods yield ensemble profiles that are insensitive …

Parallel single-cell sequencing protocols represent powerful methods for investigating
regulatory relationships, including epigenome-transcriptome interactions. Here, we report a …

Single-cell RNA sequencing can reveal the transcriptional state of cells, yet provides little
insight into the upstream regulatory landscape associated with open or accessible …

The long-range interactions of cis-regulatory elements (cREs) play a central role in gene
regulation. cREs can be characterized as accessible chromatin sequences. However, it …

Single-cell molecular profiling technologies are gaining rapid traction, but the manual
process by which resulting cell types are typically annotated is labor intensive and rate …

We report the application of single-molecule-based sequencing technology for high-
throughput profiling of histone modifications in mammalian cells. By obtaining over four …

Over the past decade, genome-wide assays for chromatin interactions in single cells have
enabled the study of individual nuclei at unprecedented resolution and throughput. Current …

Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …

Gaining insights into the regulatory mechanisms that underlie the transcriptional variation
observed between individual cells necessitates the development of methods that measure …

Higher-order genome organization and its variation in different cellular conditions remain
poorly understood. Recent high-coverage genome-wide chromatin interaction mapping …