Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish

SSL Gwee, RAW Radford, S Chow, MD Syal… - Cellular and Molecular …, 2018 - Springer
Aurora kinase B (AurkB) is a serine/threonine protein kinase with a well-characterised role in
orchestrating cell division and cytokinesis, and is prominently expressed in healthy …

AURKB and MAPK involvement in the regulation of the early stages of mouse zygote development

L Xu, T Liu, F Han, ZH Zong, GL Wang, BZ Yu… - Science China Life …, 2012 - Springer
Aurora kinases have become a hot topic for research as they have been found to play an
important role in various stages of mitotic cell division and to participate in malignant …

Depletion of Aurora‐A in zebrafish causes growth retardation due to mitotic delay and p53‐dependent cell death

HY Jeon, H Lee - The FEBS Journal, 2013 - Wiley Online Library
Aurora‐A is a serine/threonine mitotic kinase that is required for centrosome maturation.
Many cancer cells over‐express Aurora‐A, and several reports have suggested that Aurora …

Insights into the non-mitotic functions of Aurora kinase A: more than just cell division

G Bertolin, M Tramier - Cellular and Molecular Life Sciences, 2020 - Springer
AURKA is a serine/threonine kinase overexpressed in several cancers. Originally identified
as a protein with multifaceted roles during mitosis, improvements in quantitative microscopy …

Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma

C Romain, P Paul, KW Kim, S Lee, J Qiao… - Journal of pediatric …, 2014 - Elsevier
Abstract Purpose Aurora kinase A (AURKA) overexpression is associated with poor
prognosis in neuroblastoma and has been described to upregulate VEGF in gastric cancer …

Regulating the regulator: a survey of mechanisms from transcription to translation controlling expression of mammalian cell cycle kinase Aurora A

R Cacioppo, C Lindon - Open Biology, 2022 - royalsocietypublishing.org
Aurora Kinase A (AURKA) is a positive regulator of mitosis with a strict cell cycle-dependent
expression pattern. Recently, novel oncogenic roles of AURKA have been uncovered that …

[HTML][HTML] Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma

D Bogen, JS Wei, DO Azorsa, P Ormanoglu… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Despite advances in multimodal treatment, neuroblastoma (NB) is often fatal for children
with high-risk disease and many survivors need to cope with long-term side effects from high …

[HTML][HTML] Aurora kinase B expression, its regulation and therapeutic targeting in human retinoblastoma

NA Borah, S Sradhanjali, MR Barik… - … & Visual Science, 2021 - tvst.arvojournals.org
Purpose: Aurora kinase B (AURKB) plays a pivotal role in the regulation of mitosis and is
gaining prominence as a therapeutic target in cancers; however, the role of AURKB in …

The significant others of aurora kinase a in cancer: combination is the key

K Nikhil, K Shah - Biomarker Research, 2024 - Springer
AURKA is predominantly famous as an essential mitotic kinase. Recent findings have also
established its critical role in a plethora of other biological processes including ciliogenesis …

Haploinsufficient tumor suppressor Tip60 negatively regulates oncogenic Aurora B kinase

A Bose, S Sudevan, VJ Rao, H Shima, AK Trivedi… - Journal of …, 2019 - Springer
The Aurora kinases represent a group of serine/threonine kinases which are crucial
regulators of mitosis. Dysregulated Aurora kinase B (AurkB) expression, stemming from …