β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial
agents for treating both Gram-negative and Gram-positive bacterial infections. The β-lactam …

Since the 1940s β-lactam antibiotics have been used to treat bacterial infections. However,
emergence and dissemination of β-lactam resistance has reached the point where many …

The increasing incidence and prevalence of multi-drug resistance (MDR) among
contemporary Gram-negative bacteria represents a significant threat to human health. Since …

Since the discovery of penicillin by Alexander Fleming in 1929 as a therapeutic agent
against staphylococci, β-lactam antibiotics (BLAs) remained the most successful antibiotic …

Antibacterial resistance towards the β-lactam (BL) drugs is now ubiquitous, and there is a
major global health concern associated with the emergence of new β-lactamases (BLAs) as …

ABSTRACT Introduction: Antimicrobial resistance in Gram-negative pathogens is a
significant threat to global health. β-Lactams (BL) are one of the safest and most-prescribed …

Recent regulatory approvals for the β-lactam inhibitor combinations of ceftazidime–
avibactam and meropenem–vaborbactam have provided two novel therapeutic options for …

Resistance in Gram-negative bacteria to β-lactam drugs is mediated primarily by the
expression of β-lactamases, and co-dosing of β-lactams with a β-lactamase inhibitor (BLI) is …

Abstract β-lactam antibiotics are one of the most commonly used drugs for treating bacterial
infections, but their clinical effectiveness has been severely affected with bacteria …

Abstract β-Lactam antibiotics are the most commonly prescribed antibiotics worldwide;
however, antimicrobial resistance (AMR) is a global challenge. The β-lactam resistance in …