Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications

G Hajishengallis - Periodontology 2000, 2022 - Wiley Online Library
Periodontitis, a microbiome‐driven inflammatory disease of the tooth‐attachment apparatus,
is epidemiologically linked with other disorders, including cardio‐metabolic, cognitive …

Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

P Holmstrup, C Damgaard, I Olsen… - Journal of oral …, 2017 - Taylor & Francis
Increasing evidence has suggested an independent association between periodontitis and
a range of comorbidities, for example cardiovascular disease, type 2 diabetes, rheumatoid …

[HTML][HTML] Periodontal inflammation and systemic diseases: an overview

M Martínez-García, E Hernández-Lemus - Frontiers in physiology, 2021 - frontiersin.org
Periodontitis is a common inflammatory disease of infectious origins that often evolves into a
chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis …

The two‐way association of periodontal infection with systemic disorders: An overview

R Nagpal, Y Yamashiro, Y Izumi - Mediators of inflammation, 2015 - Wiley Online Library
Oral cavity that harbors diverse bacterial populations could also act as a site of origin for
spread of pathogenic microorganisms to different body sites, particularly in …

The impact of periodontal infection on systemic diseases

S Amar, X Han - Medical Science Monitor, 2003 - medscimonit.com
Systemic health is often closely linked to the state of the oral cavity: many systemic diseases
and conditions have oral manifestations. Likewise, oral microbiological infections may also …

Mapping the pathogenesis of periodontitis: a new look

KS Kornman - Journal of periodontology, 2008 - Wiley Online Library
Chronic adult periodontitis is a bacterially induced chronic inflammatory disease that
destroys the connective tissue and bone that support teeth. Concepts of the specific …

[HTML][HTML] Periodontitis: a multifaceted disease of tooth-supporting tissues

E Könönen, M Gursoy, UK Gursoy - Journal of clinical medicine, 2019 - mdpi.com
Periodontitis is an infection-driven inflammatory disease in which the composition of biofilms
plays a significant role. Dental plaque accumulation at the gingival margin initiates an …

[HTML][HTML] Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

G Hajishengallis, T Chavakis - Nature Reviews Immunology, 2021 - nature.com
Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically
associated with other chronic inflammation-driven disorders, including cardio-metabolic …

Periodontal disease and systemic conditions: a bidirectional relationship

J Kim, S Amar - Odontology, 2006 - Springer
For decades, physicians and dentists have paid close attention to their own respective fields,
specializing in medicine pertaining to the body and the oral cavity, respectively. However …

Rethinking periodontal inflammation

S Offenbacher, SP Barros, JD Beck - Journal of periodontology, 2008 - Wiley Online Library
Clinical signs and symptoms, as well as medical and dental history, are all considered in the
clinical determination of gingival inflammation and periodontal disease severity. However …