The role of the microbiota in periodontal disease

MA Curtis, PI Diaz, TE Van Dyke - Periodontology 2000, 2020 - Wiley Online Library
The last decade has witnessed unparalleled advances in our understanding of the
complexity of the oral microbiome and the compositional changes that occur in subgingival …

Can Systemic Diseases Co-induce (Not Just Exacerbate) Periodontitis? A Hypothetical “Two-hit” Model

LM Golub, JB Payne, RA Reinhardt… - Journal of dental …, 2006 - journals.sagepub.com
The connection between systemic diseases and chronic destructive periodontitis (CDP) has
received increasing attention in recent years. A major unanswered question is how disease …

Periodontitis and systemic diseases: a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases

GJ Linden, MC Herzberg… - Journal of …, 2013 - Wiley Online Library
Background: There has been an explosion in research into possible associations between
periodontitis and various systemic diseases and conditions. Aim: To review the evidence for …

Effects of periodontal disease on systemic health

R Hegde, KH Awan - Disease-a-month, 2019 - Elsevier
About one in two adults in the United States has periodontal disease. Chronic periodontitis
is an oral disease affecting the supporting structures of the teeth leading to progressive loss …

An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis

PM Bartold, TE Van Dyke - Journal of clinical periodontology, 2019 - Wiley Online Library
Background Historically, inflammatory periodontal diseases (gingivitis and periodontitis)
have been recognized as being primarily of bacterial origin. Bacteria are necessary for …

Associations between periodontal disease and systemic disease: evaluating the strength of the evidence

T Dietrich, RI Garcia - Journal of periodontology, 2005 - Wiley Online Library
Much work has been published on the association between periodontal disease and
systemic disease, including original reports, narrative reviews, systematic reviews, and meta …

Low‐grade inflammation in chronic infectious diseases: paradigm of periodontal infections

NM Moutsopoulos, PN Madianos - … of the New York Academy of …, 2006 - Wiley Online Library
Increasing evidence implicates periodontitis, a chronic inflammatory disease of the tooth‐
supporting structures, as a potential risk factor for increased morbidity or mortality for several …

Dysbiosis revisited: Understanding the role of the oral microbiome in the pathogenesis of gingivitis and periodontitis: A critical assessment

FA Scannapieco… - Journal of …, 2021 - Wiley Online Library
This commentary provides background, historical context, and a critical assessment of the
concept that microbial dysbiosis drives the pathogenesis of periodontal diseases. It is long …

Periodontal health and disease in the context of systemic diseases

G Isola, S Santonocito, SM Lupi, A Polizzi… - Mediators of …, 2023 - Wiley Online Library
During recent years, considerable progress has been made in understanding the
etiopathogenesis of periodontitis in its various forms and their interactions with the host …

Host-pathogen interactions in progressive chronic periodontitis

M Hernández, N Dutzan… - Journal of dental …, 2011 - journals.sagepub.com
Periodontitis is an infection characterized by the occurrence of supporting tissue destruction
with an episodic nature. Disease progression is often determined by the loss of attachment …