Interleukin-6 is a biomarker for the development of fatal severe acute respiratory syndrome coronavirus 2 pneumonia

A Santa Cruz, A Mendes-Frias, AI Oliveira… - Frontiers in …, 2021 - frontiersin.org
Hyper-inflammatory responses induced by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are a major cause of disease severity and death. Predictive prognosis …

The anti-inflammatory cytokine response characterized by elevated interleukin-10 is a stronger predictor of severe disease and poor outcomes than the pro …

BM Henry, SW Benoit, J Vikse, BA Berger… - Clinical Chemistry and …, 2021 - degruyter.com
Objectives Severe coronavirus disease 2019 (COVID-19) is associated with a dysregulated
immune state. While research has focused on the hyperinflammation, little research has …

Dynamic interleukin-6 level changes as a prognostic indicator in patients with COVID-19

Z Liu, J Li, D Chen, R Gao, W Zeng, S Chen… - Frontiers in …, 2020 - frontiersin.org
Background Interleukin-6 (IL-6), a proinflammatory cytokine, has been reported to be
associated with disease severity and mortality in patients with coronavirus disease 2019 …

Pro-and anti-inflammatory responses in severe COVID-19-induced acute respiratory distress syndrome—an observational pilot study

Q Notz, M Schmalzing, F Wedekink… - Frontiers in …, 2020 - frontiersin.org
Objectives The severity of Coronavirus Disease 2019 (COVID-19) is largely determined by
the immune response. First studies indicate altered lymphocyte counts and function …

Circulating levels of interleukin-6 and interleukin-10, but not tumor necrosis factor-alpha, as potential biomarkers of severity and mortality for COVID-19: systematic …

W Udomsinprasert, J Jittikoon… - Journal of clinical …, 2021 - Springer
Purpose Cytokine storm, an uncontrolled overproduction of inflammatory cytokines
contributing to an aberrant systemic inflammatory response, is a major pathological feature …

Serum interleukin-6 is an indicator for severity in 901 patients with SARS-CoV-2 infection: a cohort study

J Zhang, Y Hao, W Ou, F Ming, G Liang, Y Qian… - Journal of translational …, 2020 - Springer
Abstract Background Interleukin-6 (IL-6) was proposed to be associated with the severity of
coronavirus disease 2019 (COVID-19). The present study aimed to explore the kinetics of IL …

Interleukin-8 as a biomarker for disease prognosis of coronavirus disease-2019 patients

L Li, J Li, M Gao, H Fan, Y Wang, X Xu, C Chen… - Frontiers in …, 2021 - frontiersin.org
The widespread prevalence of coronavirus disease-2019 (COVID-19) which is caused by
severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has resulted in a severe …

Cytokines and their relationship with the severity and prognosis of coronavirus disease 2019 (COVID-19): a retrospective cohort study

QQ Liu, A Cheng, Y Wang, H Li, L Hu, X Zhao… - BMJ open, 2020 - bmjopen.bmj.com
Objective To delineate the characteristics and clinical significance of plasma inflammatory
cytokines altered in COVID-19. Design Retrospective, single-centre cohort study. Setting …

Exuberant elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection is associated with disease severity and fatal outcome

Y Yang, C Shen, J Li, J Yuan, M Yang, F Wang, G Li… - MedRxiv, 2020 - medrxiv.org
The outbreak of Coronavirus Disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, December 2019 …

Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis

J Gorham, A Moreau, F Corazza, L Peluso… - PLoS …, 2020 - journals.plos.org
Introduction Coronavirus disease 2019 (COVID-19) appeared in China in December 2019
and has spread around the world. High Interleukin-6 (IL-6) levels in COVID-19 patients …