Dysregulation, functional implications, and prognostic ability of the circadian clock across cancers

Z Liu, K Yu, J Zheng, H Lin, Q Zhao, X Zhang… - Cancer …, 2019 - Wiley Online Library
It has been proposed that the circadian rhythm generally plays important roles in tumor
suppression, but there is also evidence that disruption of the canonical circadian pathway …

Escaping circadian regulation: an emerging hallmark of cancer?

R El-Athman, A Relógio - Cell systems, 2018 - cell.com
Escaping Circadian Regulation: An Emerging Hallmark of Cancer?: Cell Systems Skip to
Main Content Skip to Main Menu Advertisement Cell Systems This journal offers authors two …

Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

WH Chang, AG Lai - Journal of translational medicine, 2019 - Springer
Background The circadian clock governs a large variety of fundamentally important
physiological processes in all three domains of life. Consequently, asynchrony in …

[HTML][HTML] The role of circadian clocks in cancer: Mechanisms and clinical implications

H Liu, Y Liu, R Hai, W Liao, X Luo - Genes & Diseases, 2023 - Elsevier
Circadian rhythm refers to the inherent 24-h cycle oscillation of biochemical, physiological
and behavioral functions, which is almost universal in eukaryotes. At least 14 core clock …

A profound relationship between circadian rhythm dysfunction and cancer progression: An approach to exploration

S Samanta - Critical Reviews™ in Oncogenesis, 2021 - dl.begellhouse.com
ABSTRACT Circadian (~ 24-hour) rhythm has been observed in all living organisms. In
humans, the circadian system governs different physiological functions such as metabolism …

Circadian clocks, epigenetics, and cancer

S Masri, K Kinouchi… - Current opinion in …, 2015 - journals.lww.com
Circadian clocks, epigenetics, and cancer : Current Opinion in Oncology Circadian clocks,
epigenetics, and cancer : Current Opinion in Oncology Log in or Register Subscribe to …

Circadian oscillations persist in cervical and esophageal cancer cells displaying decreased expression of tumor-suppressing circadian clock genes

PJ van der Watt, LC Roden, KT Davis, MI Parker… - Molecular Cancer …, 2020 - AACR
There is accumulating evidence for a link between circadian clock disruption and cancer
progression. In this study, the circadian clock was investigated in cervical and esophageal …

Disruption of clock gene expression in human colorectal liver metastases

SA Huisman, AR Ahmadi, JNM IJzermans, C Verhoef… - Tumor Biology, 2016 - Springer
The circadian timing system controls about 40% of the transcriptome and is important in the
regulation of a wide variety of biological processes including metabolic and proliferative …

Altered expression of circadian clock genes in head and neck squamous cell carcinoma

CM Hsu, SF Lin, CT Lu, PM Lin, MY Yang - Tumor Biology, 2012 - Springer
Head and neck squamous cell carcinoma (HNSCC) means a group of cancers developed
from the upper aerodigestive tract, and 90% of them are squamous cell carcinomas. HNSCC …

Understanding the significance of biological clock and its impact on cancer incidence

S Malik, J Stokes III, U Manne, R Singh, MK Mishra - Cancer letters, 2022 - Elsevier
The circadian clock is an essential timekeeper that controls, for humans, the daily rhythm of
biochemical, physiological, and behavioral functions. Irregular performance or disruption in …