Aging is characterized by a significant decline of metabolic and hormonal functions, which
often facilitates the onset of severe age-associated pathologies. One outstanding example of …

In different clinical studies, an association of type 2 diabetes and Alzheimer's disease (AD)
has been described. However, the underlying mechanisms are still unclear. One …

Insulin like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) signalling control vital
growth, survival and metabolic functions in the brain. Here we describe specific and …

Interest in characterizing the role of impaired insulin actions in Alzheimer's disease (AD) and
vascular dementia is growing exponentially. This review details what is currently known …

As populations across the world both age and become more obese, the numbers of
individuals with Alzheimer′ s disease and diabetes are increasing; posing enormous …

Alzheimer's disease (AD) is a growing problem worldwide, and there are currently no
effective treatments for this devastating disease. The neurotrophic growth factors insulin and …

Although the brain was once considered an insulin‐independent organ, insulin signalling is
now recognised as being central to neuronal health and to the function of synapses and …

The quality control of protein homoeostasis deteriorates with aging, causing the
accumulation of misfolded proteins and neurodegeneration. Thus, in AD (Alzheimer's …

The last decade has revealed that the lifespan of an organism can be modulated by the
signaling pathway that acts downstream of the insulin/insulin-like growth factor 1 receptors …

Alzheimer's disease (AD) is the most common cause of dementia in North America. Growing
evidence supports the concept that AD is fundamentally a metabolic disease that results in …