COVID-19 is caused by SARS-CoV-2 infection and characterized by diverse clinical
symptoms. Type I interferon (IFN-I) production is impaired and severe cases lead to ARDS …

The newly emerging coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, but …

The interferon pathway, a key antiviral defense mechanism, is being considered as a
therapeutic target in COVID‐19. Both, substitution of interferon and JAK/STAT inhibition to …

Hyper-inflammatory responses, lymphopenia, unbalanced immune responses, cytokine
storm, large viral replication and massive cell death play fundamental roles in the …

Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of
deaths. In search for key targets of effective therapeutics, robust animal models mimicking …

SARS-CoV-2 infection has been shown to trigger a wide spectrum of immune responses
and clinical manifestations in human hosts. Here, we sought to elucidate novel aspects of …

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused the unprecedented COVID-19 pandemic, which has infected over 178 million people …

Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), is associated with a high mortality rate …

ABSTRACT SARS-CoV-2 can infect multiple organs, including lung, intestine, kidney, heart,
liver, and brain. The molecular details of how the virus navigates through diverse cellular …

As the incidence of COVID-19 increases with time, more and more efforts are made to pave
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …