Next generation mucosal vaccine strategy for respiratory pathogens

F Dotiwala, AK Upadhyay - Vaccines, 2023 - mdpi.com
Inducing humoral and cytotoxic mucosal immunity at the sites of pathogen entry has the
potential to prevent the infection from getting established. This is different from systemic …

[HTML][HTML] Mucosal COVID-19 vaccines: Risks, benefits and control of the pandemic

D Miteva, M Peshevska-Sekulovska… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Based on mucosal immunization to promote both mucosal and systemic immune responses,
next-generation coronavirus disease 2019 (COVID-19) vaccines would be administered …

Recent advances in respiratory immunization: A focus on COVID-19 vaccines

X He, X Chen, H Wang, G Du, X Sun - Journal of Controlled Release, 2023 - Elsevier
The development of vaccines has always been an essential task worldwide since vaccines
are regarded as powerful weapons in protecting the global population. Although the vast …

[HTML][HTML] Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines

V Mouro, A Fischer - Mucosal immunology, 2022 - Elsevier
The development and deployment of vaccines against COVID-19 demonstrated major
successes in providing immunity and preventing severe disease and death. Yet SARS-CoV …

[HTML][HTML] Mucosal vaccine delivery: A focus on the breakthrough of specific barriers

M Huang, M Zhang, H Zhu, X Du, J Wang - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Mucosal vaccines can effectively induce an immune response at the mucosal site and form
the first line of defense against microbial invasion. The induced mucosal immunity includes …

Viral-vectored respiratory mucosal vaccine strategies

M Jeyanathan, S Afkhami, A Kang, Z Xing - Current Opinion in Immunology, 2023 - Elsevier
Increasing global concerns of pandemic respiratory viruses highlight the importance of
developing optimal vaccination strategies that encompass vaccine platform, delivery route …

[HTML][HTML] The unfulfilled potential of mucosal immunization

JR Baker Jr, M Farazuddin, PT Wong… - Journal of Allergy and …, 2022 - Elsevier
Recent events involving the global coronavirus pandemic have focused attention on
vaccination strategies. Although tremendous advances have been made in subcutaneous …

Mucosal vaccines for SARS-CoV-2: triumph of hope over experience

D Pilapitiya, AK Wheatley, HX Tan - EBioMedicine, 2023 - thelancet.com
Currently approved COVID-19 vaccines administered parenterally induce robust systemic
humoral and cellular responses. While highly effective against severe disease, there is …

Mucosal immunity: The missing link in comprehending SARS-CoV-2 infection and transmission

MW Russell, J Mestecky - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is primarily an airborne infection of the upper respiratory tract, which on
reaching the lungs causes the severe acute respiratory disease, COVID-19. Its first contact …

[HTML][HTML] Promises and challenges of mucosal COVID-19 vaccines

APS Rathore, ALS John - Vaccine, 2023 - Elsevier
Abstract Coronavirus disease-2019 (COVID-19) is an ongoing pandemic caused by the
newly emerged virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …