Response to corticosteroids in severe ulcerative colitis: a systematic review of the literature and a meta-regression

D Turner, CM Walsh, AH Steinhart… - Clinical Gastroenterology …, 2007 - Elsevier
Background & Aims: Colectomy is a potentially life-saving procedure for patients with severe
attacks of UC who fail medical therapy. We aimed to systematically review studies that …

Predicting the outcome of corticoid therapy for acute ulcerative colitis: results of a prospective, randomized, double-blind clinical trial

S Meyers, PK Lerer, EJ Feuer… - Journal of clinical …, 1987 - journals.lww.com
We looked for factors predicting the therapeutic outcome in 66 patients with severe
ulcerative colitis treated with intravenous hydrocortisone or corticotropin (ACTH) for 10 days …

Outcome of a conservative approach in severe ulcerative colitis

M Daperno, R Sostegni, N Scaglione, E Ercole… - Digestive and Liver …, 2004 - Elsevier
Background. Severe ulcerative colitis is potentially life threatening even though a policy of
intensive medical management and early colectomy in recent years reduced mortality to …

Mucosal healing predicts late outcomes after the first course of corticosteroids for newly diagnosed ulcerative colitis

S Ardizzone, A Cassinotti, P Duca, C Mazzali… - Clinical …, 2011 - Elsevier
BACKGROUND & AIMS: It is uncertain whether mucosal healing after the first course of
corticosteroids therapy predicts outcome in patients with ulcerative colitis (UC). We …

Systematic review and meta-analysis: infliximab or cyclosporine as rescue therapy in patients with severe ulcerative colitis refractory to steroids

N Narula, JK Marshall, JF Colombel… - Official journal of the …, 2016 - journals.lww.com
OBJECTIVES: Acute severe steroid-refractory ulcerative colitis (UC) carries a poor prognosis
and requires optimal management. A systematic review and meta-analysis were conducted …

Predicting the outcome of severe ulcerative colitis: development of a novel risk score to aid early selection of patients for second‐line medical therapy or surgery

GT Ho, C Mowat, CJR Goddard… - Alimentary …, 2004 - Wiley Online Library
Background: The failure rate of medical therapy in severe ulcerative colitis is high. A risk
index, to aid the identification of patients of not responding at an early stage to intravenous …

Outcomes of salvage therapy for steroid‐refractory acute severe ulcerative colitis: ciclosporin vs. infliximab

A Croft, A Walsh, J Doecke, R Cooley… - Alimentary …, 2013 - Wiley Online Library
Background Up to 40% of patients who present with acute severe ulcerative colitis (UC) fail
to make an adequate response to intravenous corticosteroids. Ciclosporin or infliximab are …

Continuous infusion versus bolus administration of steroids in severe attacks of ulcerative colitis: a randomized, double-blind trial

F Bossa, S Fiorella, N Caruso, L Accadia… - Official journal of the …, 2007 - journals.lww.com
BACKGROUND In patients with severe attacks of ulcerative colitis (UC), IV steroids
represent the first-line treatment, leading to clinical improvement in approximately 50–60 …

A current overview of corticosteroid use in active ulcerative colitis

M Salice, F Rizzello, C Calabrese… - Expert review of …, 2019 - Taylor & Francis
Introduction: Ulcerative colitis (UC) is a chronic inflammatory condition that causes
continuous mucosal inflammation of the colon. New biological drugs have been developed …

Treatment of hospitalized adult patients with severe ulcerative colitis: Toronto consensus statements

A Bitton, D Buie, R Enns, BG Feagan… - Official journal of the …, 2012 - journals.lww.com
OBJECTIVES: The objective of this study was to provide updated explicit and relevant
consensus statements for clinicians to refer to when managing hospitalized adult patients …