Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …

Summary (Macro) autophagy is a fundamental degradation process for macromolecules and
organelles of vital importance for cell and tissue homeostasis. Autophagy research has …

Autophagy is an essential recycling and quality control pathway. Mammalian ATG8 proteins
drive autophagosome formation and selective removal of protein aggregates and organelles …

In autophagic processes a variety of cargos is delivered to the degradative compartment of
cells. Recent progress in autophagy research has provided support for the notion that when …

Selective autophagy is critical for regulating cellular homeostasis by mediating lysosomal
turnover of a wide variety of substrates including proteins, aggregates, organelles, and …

Autophagy is a non‐selective bulk degradation process in which isolation membranes
enclose a portion of cytoplasm to form double‐membrane vesicles, called autophagosomes …

Autophagy is an evolutionarily conserved degradation pathway characterized by dynamic
rearrangement of membranes that sequester cytoplasm, protein aggregates, organelles, and …

Membrane targeting of autophagy‐related complexes is an important step that regulates
their activities and prevents their aberrant engagement on non‐autophagic membranes …

During autophagy, vesicle dynamics and cargo recruitment are driven by numerous
adaptors and receptors that become tethered to the phagophore through interactions with …

Selective autophagy requires the specific segregation of targeted proteins into
autophagosomes. The selectivity is mediated by autophagy receptors, such as p62 and …