Accumulating evidence suggests that activation of spinal microglia contributes to the
development of inflammatory and neuropathic pain. However, the role of spinal microglia in …

This study highlights the supraspinal glial mechanism underlying the induction of bone
cancer pain and provides a new potential target for the treatment of cancer pain. ABSTRACT …

Protein tyrosine phosphorylation has been implicated in normal and pathological functions
such as cell proliferation, migration and differentiation. Recently, some studies have shown …

Bone cancer pain remains a major challenge in patients with primary or metastatic bone
cancer due to a lack of understanding the mechanisms. Previous studies have revealed the …

The pharmacological attenuation of glial activation represents a novel approach for
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …

Glial cell hyperactivity has been proposed to be responsible for chronic pain, however, the
mechanisms remain unclear. Interleukin (IL)-18, released from glial cells, has been reported …

Interleukin (IL)-18 is an important regulator of innate and acquired immune responses. Here
we show that both the IL-18 and IL-18 receptor (IL-18R), which are induced in spinal dorsal …

It has been reported that remarkable and sustained activation of astrocytes and/or microglia
occurs in cancer induced pain (CIP), which is different from neuropathic and inflammatory …

Accumulating evidence suggests that chemokine monocyte chemoattractant protein-1 (MCP-
1) is significantly involved in the activation of spinal microglia associated with pathological …

Neuronal plasticity along the pathway for sensory transmission including the spinal cord and
cortex plays an important role in chronic pain, including inflammatory and neuropathic pain …