Metallo-β-lactamases are the latest resistance mechanism of pathogenic and opportunistic
bacteria against carbapenems, considered as last resort drugs. The worldwide spread of …

β‐Lactam antibiotics are the most commonly used antibacterial agents and growing
resistance to these drugs is a concern. Metallo‐β‐lactamases are a diverse set of enzymes …

Metallo-β-lactamases are broad-spectrum zinc enzymes, able to inactivate most clinically
useful β-lactam antibiotics. Their structural and functional diversity has thus far limited the …

β-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low
toxicity and broad spectrum. Their action is counteracted by different resistance mechanisms …

Metallo-β-lactamases are a subset of zinc hydrolases able to hydrolyze the β-lactam ring of
several antibiotics. The number of structural and mechanistic studies on these …

This past year has produced determinations of X-ray crystal structures for three metallo-β-
lactamases and the elucidation of the catalytic mechanisms for a monozinc and a dizinc …

The initial nucleophilic substitution step of biapenem hydrolysis catalyzed by a subclass B2
metallo-β-lactamase (CphA from Aeromonas hydrophila) is investigated using hybrid …

Background The metallo-β-lactamases are Zn (II)-containing enzymes that hydrolyze the β-
lactam bond in penicillins, cephalosporins, and carbapenems and are involved in bacterial …

Carbapenem-resistant Enterobacteriaceae threaten human health, since carbapenems are
last resort drugs for infections by such organisms. Metallo-β-lactamases (MβLs) are the main …

Metallo-β-lactamases represent an emerging clinical threat due to their ability to render
ineffective an entire class of antibiotics. Accordingly, this family of enzymes has been …