The role of cholesterol metabolism in Alzheimer's disease

JH Sun, JT Yu, L Tan - Molecular neurobiology, 2015 - Springer
Alzheimer's disease (AD) is the most common type of dementias and becoming a worldwide
problem. As the time goes by, more and more researches show that AD is related to …

Novel therapeutic strategies for Alzheimer's disease targeting brain cholesterol homeostasis

NP Samant, GL Gupta - European Journal of Neuroscience, 2021 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia. Aβ plaques and tauopathy are two major concerns associated …

The role of cholesterol in pathogenesis of Alzheimer's disease: dual metabolic interaction between amyloid β-protein and cholesterol

M Michikawa - Molecular neurobiology, 2003 - Springer
The implication that cholesterol plays an essential role in the pathogenesis of Alzheimer's
disease (AD) is based on the 1993 finding that the presence of apolipoprotein E (apoE) …

Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer's disease

V Rudajev, J Novotny - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder that is one of the most
devastating and widespread diseases worldwide, mainly affecting the aging population. One …

Cholesterol dysmetabolism in Alzheimer's disease: a starring role for astrocytes?

E Staurenghi, S Giannelli, G Testa, B Sottero… - Antioxidants, 2021 - mdpi.com
In recent decades, the impairment of cholesterol metabolism in the pathogenesis of
Alzheimer's disease (AD) has been intensively investigated, and it has been recognized to …

Cholesterol metabolism in neurodegenerative diseases: molecular mechanisms and therapeutic targets

L Dai, L Zou, L Meng, G Qiang, M Yan, Z Zhang - Molecular neurobiology, 2021 - Springer
Cholesterol is an indispensable component of the cell membrane and plays vital roles in
critical physiological processes. Brain cholesterol accounts for a large portion of total …

Alzheimer's disease: cholesterol a menace?

A Mathew, Y Yoshida, T Maekawa, DS Kumar - Brain research bulletin, 2011 - Elsevier
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease manifested by
cognitive and memory deterioration, culminating in a spectrum of neuropsychiatric …

Role of cholesterol in APP metabolism and its significance in Alzheimer's disease pathogenesis

M Maulik, D Westaway, JH Jhamandas, S Kar - Molecular neurobiology, 2013 - Springer
Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder believed to
be initiated by accumulation of amyloid β (Aβ)-related peptides derived from proteolytic …

Lipids as key players in Alzheimer disease-Alterations in metabolism and genetics

FG Sagin, EY Sozmen - Current Alzheimer Research, 2008 - ingentaconnect.com
Advances in Alzheimer Disease (AD) research suggest that central nervous system (CNS)
lipids play a key role in the pathogenesis. This role is attributed to the rich lipid content of …

Connecting the dots between hypercholesterolemia and Alzheimer's disease: a potential mechanism based on 27-hydroxycholesterol

M Wu, Y Zhai, X Liang, W Chen, R Lin, L Ma… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD), the most common cause of dementia, is a complex and
multifactorial disease involving genetic and environmental factors, with …