Cholesterol is an essential component of membranes for maintaining their structure and
functions. The discovery that possession of apolipoprotein E (apoE), allele ϵ4 is a strong …

Since the discovery of the significance of the cholesterol-carrying apolipoprotein E and
cholesterolaemia as major risk factors for Alzheimer's Disease (AD) there has been a …

A hallmark of all forms of Alzheimer's disease (AD) is an abnormal accumulation of the β-
amyloid protein (Aβ) in specific brain regions. Both the generation and clearance of Aβ are …

Article abstract—The Aβ-amyloid peptide (Aβ), the main component of amyloid plaques, is
derived by proteolytic cleavage from the amyloid precursor protein (APP). Epidemiologic …

Cholesterol is an essential component of mammalian cell membranes and a precursor for
crucial signaling molecules. The brain contains the highest level of cholesterol in the body …

Lipids are an essential component of cellular bilayer membranes and the major energy
reserve in cells and tissues; lipid homeostasis is crucial for normal cell morphology, integrity …

Alzheimer's disease (AD) is a neurodegenerative disorder that causes severe and
progressive cognitive impairment. The discovery of specific mutations related to AD …

Alzheimer's disease (AD) is caused by several risk factors leading to dementia. It's diagnosis
usually depends on clinical presentation and certain biomarkers in the cerebrospinal fluid …

Background Alzheimer's disease (AD) is a neurodegenerative disorder and the leading
cause of dementia in the elderly. The two hallmark lesions in AD brain are deposition of …

Alzheimer's disease (AD) is a devastating neurocognitive disorder rapidly growing across
the elderly population. Although few cases arise due to genetic mutations, sporadic AD is …