CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease

F Djelti, J Braudeau, E Hudry, M Dhenain, J Varin… - Brain, 2015 - academic.oup.com
Abnormalities in neuronal cholesterol homeostasis have been suspected or observed in
several neurodegenerative disorders including Alzheimer's disease, Parkinson's disease …

Cholesterol in Alzheimer's disease: unresolved questions

M Stefani, G Liguri - Current Alzheimer Research, 2009 - ingentaconnect.com
The role of cholesterol as a susceptibility factor or a protective agent in neurodegeneration
and, more generally, in amyloid-induced cytotoxicity is still controversial. Epidemiological …

Lipids and lipoproteins may play a role in the neuropathology of Alzheimer's disease

O Akyol, S Akyol, MC Chou, S Chen, CK Liu… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) and other classes of dementia are important public health
problems with overwhelming social, physical, and financial effects for patients, society, and …

Role of cholesterol metabolism in the pathogenesis of Alzheimer's disease

B Allinquant, C Clamagirand… - Current Opinion in Clinical …, 2014 - journals.lww.com
Role of cholesterol metabolism in the pathogenesis of Alzhei... : Current Opinion in Clinical
Nutrition & Metabolic Care Role of cholesterol metabolism in the pathogenesis of …

Involvement of cholesterol in the pathogenesis of Alzheimer's disease: role of statins.

P Pregelj - Psychiatria Danubina, 2008 - europepmc.org
Alzheimer's disease (AD) is a slowly, progressive neurodegenerative disorder that is the
most common cause of dementia in elderly people. On the other hand, cerebrovascular …

Inflammation drives Alzheimer's disease: emphasis on 5-lipoxygenase pathways

A Siddiqui, S Akhtar, Z Shah, I Othman… - Current …, 2021 - ingentaconnect.com
It is a known fact that inflammation affects several physiological processes, including the
functioning of the central nervous system. Additionally, impairment of lipid …

A fluid connection: cholesterol and Aβ

B Wolozin - Proceedings of the National Academy of …, 2001 - National Acad Sciences
Alzheimer's disease (AD) has long been in the public eye because of its prevalence in the
geriatric population, and the fear that the cognitive haze of dementia will strike us. The …

Dyslipidemia and the risk of Alzheimer's disease

C Reitz - Current atherosclerosis reports, 2013 - Springer
Whether cholesterol is implicated in the pathogenesis of Alzheimer's disease (AD) is still
controversial. Several studies that explored the association between lipids and/or lipid …

Alzheimer's disease: the lipid connection

T Hartmann, J Kuchenbecker… - Journal of …, 2007 - Wiley Online Library
Alzheimer's disease is the most common neurodegenerative disorder. This short review
summarizes the current knowledge about the role of lipids, especially cholesterol …

Lipids at the nexus between cerebrovascular disease and vascular dementia: The impact of HDL-cholesterol and ceramides

D Sergi, E Zauli, V Tisato, P Secchiero, G Zauli… - International Journal of …, 2023 - mdpi.com
Cerebrovascular diseases and the subsequent brain hypoperfusion are at the basis of
vascular dementia. Dyslipidemia, marked by an increase in circulating levels of triglycerides …