By combining transcriptomic data with other data sources, inferences can be made about
functional changes during ageing. Thus, we conducted a meta-analysis on 127 publicly …

Aging in humans is an incredibly complex biological process that leads to increased
susceptibility to various diseases. Understanding which genes are associated with healthy …

Aging is a complex process that can be characterized by functional and cognitive decline in
an individual. Aging can be assessed based on the functional capacity of vital organs and …

Motivation: Numerous microarray studies of aging have been conducted, yet given the noisy
nature of gene expression changes with age, elucidating the transcriptional features of …

Aging is accompanied by the functional decline of tissues. However, a systematic study of
epigenomic and transcriptomic changes across tissues during aging is missing. Here, we …

A key goal of aging research was to understand mechanisms underlying healthy aging and
develop methods to promote the human healthspan. One approach is to identify gene …

Gene expression alterations occurring with aging have been described for a multitude of
species, organs, and cell types. However, most of the underlying studies rely on static …

Background The biological mechanisms that underlie aging have not yet been fully
identified. Senescence, a phenomenon occurring in vitro, limits the number of cell divisions …

Background Identifying biological pathways that vary across the age spectrum can provide
insight into fundamental mechanisms that impact disease and frailty in the elderly. Few …

Highlights•Aging transcriptomes consist of regulated and dysregulated gene expression
changes.•Dysregulated transcriptional changes can be random (noise) or non-random …