The molecular characteristics of aging that lead to increased disease susceptibility remain
poorly understood. Here we present a transcriptomic profile of the human brain associated …

Although studies over the last decades have firmly connected a number of genes and
molecular pathways to aging, the aging process as a whole still remains poorly understood …

Background Mammalian aging is a highly complex process, a full mechanistic
understanding of which is still lacking. One way to help understand the molecular changes …

Aging is a ubiquitous biological process that limits the maximal lifespan of most organisms.
Significant efforts by many groups have identified mechanisms that, when triggered by …

Although molecular features underlying aging and species maximum lifespan (MLS) have
been comprehensively studied by transcriptome analyses, the actual impact of transcriptome …

Biological aging reflects decline in physiological functions and is an effective indicator of
morbidity and mortality. Numerous epigenetic age calculators are available, however …

Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …

The mechanistic causes of aging, the time-related decline in function and good health that
leads to increased mortality, remain poorly understood. Here we propose that age …

Aging is associated with gradual deterioration of physiological and biochemical functions,
including cognitive decline. Transcriptome profiling of brain samples from individuals of …

Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …