CYP2D6 genetic polymorphisms are considered a major contributor to the large
interindividual variability in CYP2D6‐mediated drug metabolism, but fail to explain a …

CYP2D6 is one of the most polymorphic drug-metabolizing enzymes in the liver. While
genetic CYP2D6 variants serve as clinical biomarkers to predict CYP2D6 activity, large inter …

Genetic polymorphism of cytochrome P450s results in clinically significant modifications in
patients' drug metabolizing capacities. CYP2D6 has a crucial role in the elimination of …

Abstract CYP2D6 metabolizes nearly 25% of clinically used drugs. Genetic polymorphisms
cause large inter-individual variability in CYP2D6 enzyme activity and are currently used as …

Our objectives were to identify CYP2D6 genetic polymorphisms in a Korean population, to
compare the allele frequencies with those of other ethnic groups, and to evaluate variant …

Cytochrome P450 2D6 (CYP2D6) is an enzyme of potential importance for the metabolism
of drugs used clinically, and it exhibits genetic polymorphism with interindividual differences …

Polymorphisms in the cytochrome P450 2D6 (CYP2D6) gene are a major cause of
pharmacokinetic variability in human. Although the poor metabolizer phenotype is known to …

CYP2D6 is a member of cytochrome P450 enzymes that metabolise over 25% of commonly
used drugs. Genetic polymorphisms can cause insufficient drug efficacy at usually …

Cytochrome P450 2D6 (CYP2D6) is a critical hepatic drug-metabolizing enzyme in humans,
responsible for metabolizing approximately 20%–25% of commonly used medications such …

The cytochrome P450 2D6 (CYP 2D6) gene locus is challenging to accurately genotype due
to numerous single nucleotide variants and complex structural variation. Our goal was to …