Proper regulation of the Tap-1 gene is critical for the initiation and continuation of a cellular
immune response. Analysis of the Tap-1/low molecular mass polypeptide 2 bidirectional …

With recent studies suggesting a key role for professional antigen presenting cells in the
induction of major histocompatibility class I cellular immune responses, we initiated studies …

The genes of the transporter associated with antigen processing (Tap)-1, and the low
molecular weight peptide (Lmp)-2, are crucial for class I major histocompatibility complex …

This study examines the role of the signal transducer and activator of transcription 1 (STAT1)
in induction of lipopolysaccharide (LPS)-stimulated gene expression both in vitro and in …

Complete activation of macrophages during immune responses results from stimulation with
the activating cytokine interferon‐γ (IFN‐γ) and a second stimulus, usually a microbial …

The goal of this study was to investigate how bacterial LPS affects macrophage
responsiveness to the activating factor IFN-γ. Pretreatment of macrophages with LPS for< 2 …

IFNγ, once called the macrophage-activating factor, stimulates many genes in macrophages,
ultimately leading to the elicitation of innate immunity. IFNγ's functions depend on the …

Transporter associated with Ag processing 1 and low molecular mass polypeptide 2 (LMP2)
are essential for class I MHC function and share a common bidirectional promoter. In murine …

The transcriptional regulation of the murine IP-10 gene in lipopolysaccharide (LPS) or
interferon gamma (IFN gamma)-treated macrophages was investigated by analysis of …

The regulation of macrophage activator protein-1 (AP-1) gene expression by LPS and
cytokines is of potentially crucial importance in the pathogenesis of several diseases. The …