Background Tissue-engineered bone may be developed by seeding the cells capable of
both osteogenesis and vascularization on biocompatible composite scaffolds. The current …

Natural bone growth greatly depends on the precedent vascular network that supplies
oxygen and essential nutrients and removes metabolites. Likewise, it is crucial for tissue …

In addition to a biocompatible scaffold and an osteogenic cell population, tissue‐engineered
bone requires an appropriate vascular bed to overcome the obstacle of nutrient and oxygen …

This study evaluated the potential of the PCL (poly-caprolactone)/HA (Hydroxyapatite)
composite materials as a scaffold for bone regeneration. For this, we fabricated scaffolds …

Strategies for improvement of angiogenesis and vasculogenesis using different cells and
materials are paramount aims in the field of bone tissue engineering. Thereby, the …

It is well established that vascularization is critical for osteogenesis. However, adequate
vascularization also remains one of the major challenges in tissue engineering of bone. This …

Polycaprolactone (PCL), a semicrystalline linear resorbable aliphatic polyester, is a good
candidate as a scaffold for bone tissue engineering, due to its biocompatibility and …

Vascularization of engineered bone tissue is critical for ensuring its survival after
implantation and it is the primary factor limiting its clinical use. A promising approach is to …

Mesenchymal stem cells (MSCs), a stem cell population capable of multi‑lineage
differentiation, bound to porous biomaterial scaffolds, are widely used for bone tissue …

Major drawbacks of using an autograft are the possibilities of insufficient bony source and
patient's morbidity after operation. Bone tissue engineering technology, therefore, has been …