One of the fundamental issues in RNA splicing research is represented by understanding
how the spliceosome can successfully define exons and introns in a huge variety of pre …

Pre-mRNA splicing involves removing non-coding introns from RNA transcripts. It is carried
out by the spliceosome, along with other auxiliary factors. In general, research in splicing …

The discovery in 1977 of split genes in eukaryotic genomes must rank as one of the most
surprising scientific findings of this century. Some twenty years later, a number of important …

Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene
expression. The identification of the actual splice sites and the proper removal of introns are …

The past year has witnessed refinements in models of spliceosome assembly pathways and
in the understanding of how splicing factors of the serine/arginine-rich (SR) protein family …

Alternative splicing is an important mechanism in generating proteomic diversity, and RNA
secondary structure is an important element in splicing regulation. The use of high …

Alternative splicing of pre-mRNAs is a major contributor to both proteomic diversity and
control of gene expression levels. Splicing is tightly regulated in different tissues and …

Alternative splicing is a widespread means of increasing protein diversity and regulating
gene expression in eukaryotes. Much progress has been made in understanding the …

The generation of protein coding mRNAs from pre-mRNA is a fundamental biological
process that is required for gene expression. Alternative pre-mRNA splicing is responsible …

Alternative splicing is a well‐characterized mechanism by which multiple transcripts are
generated from a single mRNA precursor. By allowing production of several protein isoforms …