Abstract Double-stranded RNA (dsRNA)–activated kinase (PKR) is an important component
in inflammation and immune dysfunction. However, the role of PKR in neuropathic pain …

Background Nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2)-induced
oxidative stress, including the production of reactive oxygen species (ROS) and hydrogen …

Peripheral nerve injury-caused hyperexcitability and abnormal ectopic discharges in the
primary sensory neurons of dorsal root ganglion (DRG) play a key role in neuropathic pain …

Inflammation of the primary afferent proximal to the dorsal root ganglion (DRG) and the DRG
itself is known to produce radicular pain. Here, we examined pain-related behaviors and the …

Injury to the peripheral nerves often induces produces spontaneous pain, hyperalgesia
(increased responsiveness to noxious stimuli), and allodynia (painful responses to normally …

The activation of glial cells in the spinal dorsal horn and the gracile nucleus by inflammation
and nerve injury has been suggested to be involved in neuronal plasticity and central …

Peripheral nerve injury resulting in neuropathic pain induces the upregulation of interleukin
(IL)-6 and tumor necrosis factor-α, which binds to tumor necrosis factor receptor 1 (TNFR1) …

Background Neuropathic pain (NP) is characterized by abnormal activation of pain
conducting pathways and manifests as mechanical allodynia and thermal hypersensitivity …

The coupling of the spinal postsynaptic density-95 (PSD-95) with the glutamatergic N-methyl-
d-aspartate receptor NR2B subunit and the subsequent NR2B phosphorylation contribute to …

Partial injury of the rat sciatic nerve elicits a variety of characteristic chemical, electrophysical
and anatomical changes in primary sensory neurons and constitutes a physiologically …