Nonstructural protein 14 (nsp14) of coronaviruses (CoV) is important for viral replication and
transcription. The N-terminal exoribonuclease (ExoN) domain plays a proofreading role for …

The≈ 30-kb coronavirus (+) RNA genome is replicated and transcribed by a membrane-
bound replicase complex made up of 16 viral nonstructural proteins (nsp) with multiple …

The severe acute respiratory syndrome coronavirus (SARS-CoV) devotes a significant
portion of its genome to producing nonstructural proteins required for viral replication. SARS …

The N7-methylguanosine (m7G) cap is the defining structural feature of eukaryotic mRNAs.
Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have …

The severe acute respiratory syndrome coronavirus (SARS-CoV) possesses a large 29.7-kb
positive-stranded RNA genome. The first open reading frame encodes replicase …

The RNA-synthesizing machinery of the severe acute respiratory syndrome Coronavirus
(SARS-CoV) is composed of 16 non-structural proteins (nsp1–16) encoded by ORF1a/1b …

The severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural proteins
nsp1 to nsp16 have been implicated by genetic analysis in the assembly of a functional …

The emerging disease SARS is caused by a novel coronavirus that encodes several
unusual RNA-processing enzymes, including non-structural protein 15 (Nsp15), a …

The severe acute respiratory syndrome (SARS) coronavirus virus non-structural protein 15 is
a Mn2+-dependent endoribonuclease with specificity for cleavage at uridylate residues. To …

Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene
expression, including type I interferon production, by promoting host mRNA degradation and …