Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations
Serum biomarker levels are associated with the risk of complex diseases. Here, we aimed to
gain insights into the genetic architecture of biomarker traits which can reflect health status …
gain insights into the genetic architecture of biomarker traits which can reflect health status …
Genetics of 35 blood and urine biomarkers in the UK Biobank
Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
Large-scale plasma proteomics comparisons through genetics and disease associations
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …
with genomic and phenotypic information have the power to bridge the gap between the …
Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses
A Demirkan, P Henneman, A Verhoeven… - PLoS …, 2015 - journals.plos.org
Metabolite quantitative traits carry great promise for epidemiological studies, and their
genetic background has been addressed using Genome-Wide Association Studies (GWAS) …
genetic background has been addressed using Genome-Wide Association Studies (GWAS) …
Genome-wide association with select biomarker traits in the Framingham Heart Study
EJ Benjamin, J Dupuis, MG Larson, KL Lunetta… - BMC medical …, 2007 - Springer
Background Systemic biomarkers provide insights into disease pathogenesis, diagnosis,
and risk stratification. Many systemic biomarker concentrations are heritable phenotypes …
and risk stratification. Many systemic biomarker concentrations are heritable phenotypes …
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background
Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and
cardiovascular diseases. We perform genetic analysis on serum levels of alanine …
cardiovascular diseases. We perform genetic analysis on serum levels of alanine …
Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
F Renström, F Payne, A Nordström… - Human molecular …, 2009 - academic.oup.com
Recent genome-wide association studies (GWAS) have identified multiple risk loci for
common obesity (FTO, MC4R, TMEM18, GNPDA2, SH2B1, KCTD15, MTCH2, NEGR1 and …
common obesity (FTO, MC4R, TMEM18, GNPDA2, SH2B1, KCTD15, MTCH2, NEGR1 and …
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
A Albrechtsen, N Grarup, Y Li, T Sparsø, G Tian, H Cao… - Diabetologia, 2013 - Springer
Aims/hypothesis Human complex metabolic traits are in part regulated by genetic
determinants. Here we applied exome sequencing to identify novel associations of coding …
determinants. Here we applied exome sequencing to identify novel associations of coding …
Cohort profile: the Oxford biobank
F Karpe, SK Vasan, SM Humphreys… - International Journal …, 2018 - academic.oup.com
Major progress has been made over the past decade in the understanding of the genetic
background to chronic metabolic disease such as type 2 diabetes (T2D) and atherosclerotic …
background to chronic metabolic disease such as type 2 diabetes (T2D) and atherosclerotic …