Bone demonstrates a remarkable ability to renew itself, adapt its architecture, and repair
fractures to maintain strength throughout life. Mechanobiology, the study of how external …

Biomechanical factors are of fundamental and recognized importance in regulation of the
musculoskeletal system. For instance, conditions such as osteopenia/osteoporosis …

Significance: Mechanosignaling is vital for maintaining the structural integrity of bone under
physiologic conditions. These signals activate and suppress multiple signaling cascades …

Bone Cell Biomechanics, Mechanobiology and Bone Diseases provides a comprehensive
overview of recent knowledge and advances of bone cell biomechanics and related bone …

Skeletal tissue is a reservoir of calcium that is important for proper muscle and nerve
function, and houses the marrow that supports the hematopoietic and mesenchymal stem …

Fracture healing is a complex, multistep process that is highly sensitive to mechanical
signaling. To optimize repair, surgeons prescribe immediate weight-bearing as-tolerated …

Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Bone remodeling is the continuous turnover of bone matrix and mineral by bone resorption
(activity of osteoclasts) and formation (activity of osteoblasts) in the adult skeleton. The …

While it has been long appreciated that biomechanical forces are involved in bone
remodeling and repair, the actual mechanism by which a physical force is translated to the …

Skeletal loading is an important physiological regulator of bone mass. Theoretically,
mechanical forces or administration of drugs that activate bone mechanosensors would be a …