Prevention and therapy of COVID-19 via exogenous estrogen treatment for both male and female patients: Prevention and therapy of COVID-19

Z Suba - Journal of Pharmacy & Pharmaceutical …, 2020 - journals.library.ualberta.ca
The presented work summarizes the results of studies underlining the crucial role of
estrogen receptor (ER) signaling in both innate and adaptive immune responses as well as …

[HTML][HTML] Therapeutic application of estrogen for COVID-19: Attenuation of SARS-CoV-2 spike protein and IL-6 stimulated, ACE2-dependent NOX2 activation, ROS …

JY Youn, Y Zhang, Y Wu, M Cannesson, H Cai - Redox biology, 2021 - Elsevier
The outbreak of COVID-19 has remained uncontained with urgent need for robust
therapeutics. We have previously reported sex difference of COVID-19 for the first time …

17β-Estradiol, a potential ally to alleviate SARS-CoV-2 infection

AC Breithaupt-Faloppa, CJ Correia, CM Prado… - Clinics, 2020 - SciELO Brasil
Considering that female sexual hormones may modulate the inflammatory response and
also exhibit direct effects on the cells of the immune system, herein, we intend to discuss the …

The looming effects of estrogen in Covid-19: a rocky rollout

HM Al-Kuraishy, AI Al-Gareeb, H Faidah… - Frontiers in …, 2021 - frontiersin.org
In the face of the Covid-19 pandemic, an intensive number of studies have been performed
to understand in a deeper way the mechanisms behind better or worse clinical outcomes …

[HTML][HTML] Could estrogen protect women from COVID-19?

R Pirhadi, VS Talaulikar, J Onwude… - Journal of clinical …, 2020 - ncbi.nlm.nih.gov
The apparent gender differences in favor of women in the risk of contracting and dying from
coronavirus disease 2019 (COVID-19), and the fact that such trends have also been …

Estrogen hormone is an essential sex factor inhibiting inflammation and immune response in COVID-19

F Li, ACM Boon, AP Michelson, RE Foraker, M Zhan… - Scientific reports, 2022 - nature.com
Although vaccines have been evaluated and approved for SARS-CoV-2 infection
prevention, there remains a lack of effective treatments to reduce the mortality of COVID-19 …

The role of estradiol in the immune response against COVID-19

A Ramirez-de-Arellano, J Gutierrez-Franco… - Hormones, 2021 - Springer
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the pathogen agent
causing coronavirus disease (COVID)-19, which was declared a global pandemic in 2020 …

[HTML][HTML] Male predisposition to severe COVID-19: Review of evidence and potential therapeutic prospects

DO Acheampong, IK Barffour, A Boye… - Biomedicine & …, 2020 - Elsevier
The severe form of COVID-19 has significant sex disparities, with high fatalities commonly
reported among males than females. The incidence of COVID-19 has also been higher in …

Sex hormones in SARS-CoV-2 susceptibility: key players or confounders?

N Lott, CE Gebhard, S Bengs, A Haider… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has a clear sex
disparity in clinical outcomes. Hence, the interaction between sex hormones, virus entry …

17β‐estradiol reduces SARS‐CoV‐2 infection in vitro

RMR Lemes, AJ Costa, CS Bartolomeo… - Physiological …, 2021 - Wiley Online Library
The COVID‐19 has originated from Wuhan, China, in December 2019 and has been
affecting the public health system, society, and economy in an unheard‐of manner. There is …