Common C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of venous thromboembolism: meta-analysis of 31 studies

JG Ray, D Shmorgun, WS Chan - Pathophysiology of haemostasis and …, 2002 - karger.com
Background: Although the common 677 C→ T polymorphism of the
methylenetetrahydrofolate reductase (MTHFR) gene is implicated in the development of …

Association between MTHFR C677T polymorphism and venous thromboembolism risk in the Chinese population: a meta-analysis of 24 case-controlled studies

P Zhang, X Gao, Y Zhang, Y Hu, H Ma, W Wang… - …, 2015 - journals.sagepub.com
The association between methylenetetrahydrofolate reductase (MTHFR) gene
polymorphisms and venous thromboembolism (VTE) risk in the Chinese population has …

Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of …

AW Tsai, M Cushman, MY Tsai… - American journal of …, 2003 - Wiley Online Library
We sought to examine prospectively the association of serum homocysteine and the
methylene tetrahydrofolate reductase (MTHFR) C677T gene polymorphism with risk of …

MTHFR A1298C and C677T polymorphisms are associated with increased risk of venous thromboembolism: a retrospective chart review study

F Liu, D Silva, MV Malone, K Seetharaman - Acta Haematologica, 2018 - karger.com
Background: Methylene tetrahydrofolate reductase (MTHFR) is a key enzyme in
homocysteine metabolism. This study aims to determine the impact of MTHFR …

No association between the common MTHFR 677C→ T polymorphism and venous thrombosis: results from the MEGA study

ID Bezemer, CJM Doggen, HL Vos… - Archives of internal …, 2007 - jamanetwork.com
Background Increased homocysteine levels are related to the occurrence of venous
thrombosis, but whether this relation is causal is unclear. The T-variant of the common …

Mutations C677T and A1298C of the 5, 10-methylenetetrahydrofolate reductase gene and fasting plasma homocysteine levels are not associated with the increased …

TB Domagala, L Adamek, E Nizankowska… - Blood coagulation & …, 2002 - journals.lww.com
Mild hyperhomocysteinemia is associated with homozygosity for the thermolabile variant of
5, 10-methylenetetrahydrofolate reductase (MTHFR) and could increase the risk of venous …

Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism …

J Frederiksen, K Juul, P Grande, GB Jensen… - Blood, 2004 - ashpublications.org
Hyperhomocysteinemia is associated with ischemic cardiovascular disease (ICD) and
venous thromboembolism (VTE). We tested the hypothesis that methylenetetrahydrofolate …

Lack of association between the C677T mutation in the 5, 10-methylenetetrahydrofolate reductase gene and venous thromboembolism in Northwestern Greece

CG Zalavras, S Giotopoulou, E Dokou… - International …, 2002 - search.proquest.com
BACKGROUND: Hyperhomocysteinemia has been associated with venous thrombosis.
Under known and unknown conditions the C677T mutation in the 5, 10 …

Correlations between methylenetetrahydrofolate reductase gene polymorphisms and venous thromboembolism: A meta-analysis of 99 genetic association studies

J Zeng, Q Zeng - European Journal of Preventive Cardiology, 2019 - academic.oup.com
We performed this meta-analysis to better assess the relationship between
methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms and the risk of venous …

Meta-analysis of the relationship between methylenetetrahydrofolate reductase C677T and A1298C polymorphism and venous thromboembolism in the Caucasian …

M Gao, N Feng, M Zhang, X Ti, X Zuo - Bioscience reports, 2020 - portlandpress.com
Recent years, it is a highly debated topic that whether methylenetetrahydrofolate reductase
(MTHFR) C677T polymorphism and A1298C polymorphism could increase susceptibility to …