Rb was the first tumour suppressor identified through human genetic studies. The most
significant achievement after almost twenty years since its cloning is the revelation that Rb …

Puzzling new information indicates an inadequacy in our understanding of the
retinoblastoma protein (RB). RB and the transcription factor E2F appear to be collaborators …

The retinoblastoma protein, Rb, is encoded by a classic tumor suppressor gene that is
mutated in a large variety of tumors. Extensive studies have suggested that Rb functions as …

The retinoblastoma gene was identified over a decade ago as the first tumor suppressor.
Although the gene was initially cloned as a result of its frequent mutation in the rare pediatric …

Studies of the retinoblastoma gene (Rb) have shown that its protein product (pRb) acts to
restrict cell proliferation, inhibit apoptosis, and promote cell differentiation. The frequent …

The retinoblastoma gene Rb was the first tumor suppressor gene cloned, and it is well
known as a negative regulator of the cell cycle through its ability to bind the transcription …

The retinoblastoma protein (pRB) is one of the best-studied tumour suppressor gene
products. Its loss during the genesis of many human tumours, its inactivation by several DNA …

In cancer cells, the retinoblastoma tumor suppressor RB is directly inactivated by mutation in
the RB gene or functionally inhibited by abnormal activation of cyclin-dependent kinase …

The retinoblastoma (RB) gene is the prototype tumor suppressor gene. It encodes a nuclear
protein that acts as a cell cycle control checkpoint at the G1 phase. Deletion or inactivation of …

The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified
and plays a fundamental role in regulation of progression through the cell cycle. This review …