Background The optimal combination drug therapy for hypertension is not established,
although current US guidelines recommend inclusion of a diuretic. We hypothesized that …

Summary Background The Avoiding Cardiovascular Events through Combination Therapy
in Patients Living with Systolic Hypertension (ACCOMPLISH) trial showed that initial …

ACCOMPLISH is the first trial designed to compare the effects on major fatal and non‐fatal
cardiovascular endpoints of two forms of antihypertensive combination therapy: benazepril …

Reducing blood pressure (BP) to target levels is a major priority in preventing clinical events
in hypertension. Typically this requires more than one drug, and recent guidelines on …

Objectives Current guidelines recommend the use of multiple medications for hypertension.
The present study was aimed at determining which combination was optimal to prevent …

Objectives: The aim of this study was to determine which combination therapy in patients
with hypertension and diabetes most effectively decreases cardiovascular events …

Abstract Background: The Seventh Report of the Joint National Committee (JNC 7) on
Prevention, Detection, Evaluation, and Treatment of High Blood Pressure recommends …

The present 2 multicenter studies were designed to evaluate whether patients with essential
hypertension derived equal benefits from use of combination therapy with a calcium …

Context Antihypertensive therapy is well established to reduce hypertension-related
morbidity and mortality, but the optimal first-step therapy is unknown. Objective To determine …

Importance Antihypertension medications have been associated with prevention of
cardiovascular events, although less is known about the comparative effectiveness of …