Characterization and structural prediction of the putative ORF10 protein in SARS-CoV-2

NA Schuster - bioRxiv, 2020 - biorxiv.org
Upstream of the 3'-untranslated region in the SARS-CoV-2 genome is ORF10 which has
been proposed to encode for the ORF10 protein. Current research is still unclear on whether …

[HTML][HTML] SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: genomic divergence and functional convergence

S Mohammad, A Bouchama, B Mohammad Alharbi… - Pathogens, 2020 - mdpi.com
The COVID-19 pandemic, in the first seven months, has led to more than 15 million
confirmed infected cases and 600,000 deaths. SARS-CoV-2, the causative agent for COVID …

[HTML][HTML] A conservative replacement in the transmembrane domain of SARS-CoV-2 ORF7a as a putative risk factor in COVID-19

A Lobiuc, D Șterbuleac, O Sturdza, M Dimian… - Biology, 2021 - mdpi.com
Simple Summary The pathogenicity and transmissibility of the COVID-19 pandemic
causative agent, the SARS-CoV-2 virus, is related to the functions of the proteins …

[HTML][HTML] Structural analysis of SARS-CoV-2 ORF8 protein: pathogenic and therapeutic implications

A Valcarcel, A Bensussen, ER Álvarez-Buylla… - Frontiers in …, 2021 - frontiersin.org
Current therapeutic strategies and vaccines against SARS-CoV-2 are mainly focused on the
Spike protein despite there are other viral proteins with important roles in COVID-19 …

Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism

X Jin, X Sun, Y Chai, Y Bai, Y Li, T Hao, J Qi… - Science China Life …, 2023 - Springer
The constant emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants indicates the evolution and adaptation of the virus. Enhanced innate immune …

Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2

L Zinzula - Biochemical and biophysical research communications, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains nine
open reading frames (ORFs) that encode for accessory proteins which, although …

A rare deletion in SARS-CoV-2 ORF6 dramatically alters the predicted three-dimensional structure of the resultant protein

MA Riojas, AM Frank, NP Puthuveetil, B Flores… - bioRxiv, 2020 - biorxiv.org
The function of the SARS-CoV-2 accessory protein p6, encoded by ORF6, is not fully known.
Based upon its similarity to p6 from SARS-CoV, it may play a similar role, namely as an …

[HTML][HTML] Variations in Orf3a protein of SARS-CoV-2 alter its structure and function

GK Azad, PK Khan - Biochemistry and biophysics reports, 2021 - Elsevier
Severe acquired respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread
worldwide and acquired multiple mutations in its genome. Orf3a, an accessory protein …

[HTML][HTML] The SARS-CoV-2 ORF10 is not essential in vitro or in vivo in humans

K Pancer, A Milewska, K Owczarek… - PLoS …, 2020 - journals.plos.org
SARS-CoV-2 genome annotation revealed the presence of 10 open reading frames (ORFs),
of which the last one (ORF10) is positioned downstream of the N gene. It is a hypothetical …

[HTML][HTML] Potential Therapeutic Target and Vaccines for SARS-CoV-2

MA Hussain, MM Hassan, BA Bashir, TA Gamar… - Pathogens, 2023 - mdpi.com
The coronavirus has become the most interesting virus for scientists because of the recently
emerging deadly SARS-CoV-2. This study aimed to understand the behavior of SARS-CoV …