Remodeling of microbiota gut-brain axis using psychobiotics in depression

MSK Palepu, MP Dandekar - European journal of pharmacology, 2022 - Elsevier
Depression is a multifaceted psychiatric disorder mainly orchestrated by dysfunction of
neuroendocrine, neurochemical, immune, and metabolic systems. The interconnection of …

Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial

A Kazemi, AA Noorbala, K Azam, MH Eskandari… - Clinical Nutrition, 2019 - Elsevier
Background Disturbance in the equilibrium of the gut microbiota has been involved in the
pathophysiology of depression. Probiotics have the potential to healthfully modulate the gut …

The anxiolytic effect of probiotics: A systematic review and meta-analysis of the clinical and preclinical literature

DJ Reis, SS Ilardi, SEW Punt - PloS one, 2018 - journals.plos.org
Background Probiotics have generated intensive research interest in recent years as a novel
mode of treatment for physical and mental illness. Nevertheless, the anxiolytic potential of …

PROVIT: Supplementary probiotic treatment and vitamin B7 in depression—A randomized controlled trial

EZ Reininghaus, M Platzer, A Kohlhammer-Dohr… - Nutrients, 2020 - mdpi.com
Gut microbiota are suspected to affect brain functions and behavior as well as lowering
inflammation status. Therefore, an effect on depression has already been suggested by …

Systematic review of evidence to support the theory of psychobiotics

AR Romijn, JJ Rucklidge - Nutrition reviews, 2015 - academic.oup.com
Context: The theory that supplemented probiotic bacteria could affect psychological
outcomes has recently been outlined in narrative reviews; to date, however, this area of …

Updated review of research on the gut microbiota and their relation to depression in animals and human beings

Z Yang, J Li, X Gui, X Shi, Z Bao, H Han, MD Li - Molecular psychiatry, 2020 - nature.com
The gut microbiota are being called the human “second brain,” as they play a key role in the
regulation of the central nervous system (CNS). Recent findings provide strong evidence for …

Major depressive disorder and gut microbiota–association not causation. A scoping review

I Łoniewski, A Misera, K Skonieczna-Żydecka… - Progress in Neuro …, 2021 - Elsevier
One very promising hypothesis of Major Depressive Disorder (MDD) pathogenesis is the gut-
brain axis (GBA) dysfunction, which can lead to subclinical inflammation, hypothalamic …

Gut microbiota–brain axis in depression: The role of neuroinflammation

AS Carlessi, LA Borba, AI Zugno… - European Journal of …, 2021 - Wiley Online Library
Major depressive disorder (MDD) is a psychiatric condition that affects a large number of
people in the world, and the treatment existents do not work for all individuals affected. Thus …

Gut microbiota in anxiety and depression: unveiling the relationships and management options

A Kumar, J Pramanik, N Goyal, D Chauhan… - Pharmaceuticals, 2023 - mdpi.com
The gut microbiota is critical for maintaining human health and the immunological system.
Several neuroscientific studies have shown the significance of microbiota in developing …

Efficacy of probiotics on stress in healthy volunteers: a systematic review and meta‐analysis based on randomized controlled trials

N Zhang, Y Zhang, M Li, W Wang, Z Liu, C Xi… - Brain and …, 2020 - Wiley Online Library
Background Probiotics seems to play a beneficial role in stressed populations; thus, a
systematic review and meta‐analysis to assess the effects of probiotics on stress in healthy …