Isolation and characterization of neural stem cells from the neonatal rat cochlear nucleus

K Rak, NV Wasielewski, A Radeloff, J Völkers… - Cell and Tissue …, 2011 - Springer
Neural stem cells have been identified in multiple parts of the postnatal mammalian brain, as
well as in the inner ear. No investigation of potential neural stem cells in the cochlear …

In vitro long-term development of cultured inner ear stem cells of newborn rat

F Carricondo, MC Iglesias, F Rodríguez… - Cell and tissue …, 2010 - Springer
The adult mammalian auditory receptor lacks any ability to repair and/or regenerate after
injury. However, the late developing cochlea still contains some stem-cell-like elements that …

Dynamic changes of the neurogenic potential in the rat cochlear nucleus during post-natal development

K Rak, J Völker, S Frenz, A Scherzed… - Experimental brain …, 2013 - Springer
Neuronal stem cells have been described in the post-natal cochlear nucleus recently. The
aim of the study was to analyse the neurogenic potential in the cochlear nucleus from the …

Cochlear nucleus whole mount explants promote the differentiation of neuronal stem cells from the cochlear nucleus in co-culture experiments

K Rak, J Völker, L Jürgens, C Völker, S Frenz… - Brain Research, 2015 - Elsevier
The cochlear nucleus is the first brainstem nucleus to receive sensory input from the
cochlea. Depriving this nucleus of auditory input leads to cellular and molecular …

Comparing the cultivated cochlear cells derived from neonatal and adult mouse

X Lou, Y Dong, J Xie, X Wang, L Yang… - Journal of translational …, 2014 - Springer
Background Previous reports showed the presence of limited numbers of stem cells in
neonatal murine cochlear sensory epithelia and these cells are progressively lost during the …

Engraftment and differentiation of embryonic stem cell–derived neural progenitor cells in the cochlear nerve trunk: Growth of processes into the organ of corti

CE Corrales, L Pan, H Li, MC Liberman… - Journal of …, 2006 - Wiley Online Library
Hearing loss in mammals is irreversible because cochlear neurons and hair cells do not
regenerate. To determine whether we could replace neurons lost to primary neuronal …

Identification of neural stem cells from postnatal mouse auditory cortex in vitro

Z Hu, L Tao, Z Liu, Y Jiang, X Deng - Stem cells and development, 2019 - liebertpub.com
Auditory signals are processed in multiple central nervous system structures, including the
auditory cortex (AC). Development of stem cell biology provides the opportunity to identify …

Differential distribution of stem cells in the auditory and vestibular organs of the inner ear

K Oshima, CM Grimm, CE Corrales, P Senn… - Journal of the …, 2007 - Springer
The adult mammalian cochlea lacks regenerative capacity, which is the main reason for the
permanence of hearing loss. Vestibular organs, in contrast, replace a small number of lost …

Survival of neural stem cells in the cochlea

J Ito, K Kojima, S Kawaguchi - Acta oto-laryngologica, 2001 - Taylor & Francis
Adult rat hippocampus-derived neural stem cells (NSCs) have been reported to have been
successfully grafted in several brain regions. To evaluate the possibility of treatment of …

A comparison of the proliferative capacity and ultrastructure of proliferative cells from the cochleae of newborn rats of different ages

C Zhong, Y Han, J Qiu, L Lu, Y Chen, J Chen… - International journal of …, 2010 - Elsevier
OBJECTIVE: Recent reports have shown that multipotent stem cells/progenitor cells that are
capable of proliferation and regeneration are present in mammalian cochleae. However …