Decoding the enigma of antiviral crisis: Does one target molecule regulate all?
Disease fatality associated with Ebola, SARS-CoV and dengue infections in humans is
attributed to a cytokine storm that is triggered by excessive pro-inflammatory responses …
attributed to a cytokine storm that is triggered by excessive pro-inflammatory responses …
Interleukin-6 perpetrator of the COVID-19 cytokine storm
J Shekhawat, K Gauba, S Gupta, P Purohit… - Indian Journal of Clinical …, 2021 - Springer
COVID-19 has emerged as a global pandemic. It is mainly manifested as pneumonia which
may deteriorate into severe respiratory failure. The major hallmark of the disease is the …
may deteriorate into severe respiratory failure. The major hallmark of the disease is the …
An ADAM17-neutralizing antibody reduces inflammation and mortality while increasing viral burden in a COVID-19 mouse model
JF Hedges, DT Snyder, A Robison… - Frontiers in …, 2022 - frontiersin.org
Angiotensin Converting Enzyme 2 (ACE2) is the primary cell entry receptor for SARS-CoV
and SARS-CoV-2 viruses. A disintegrin and metalloproteinase 17 (ADAM17) is a protease …
and SARS-CoV-2 viruses. A disintegrin and metalloproteinase 17 (ADAM17) is a protease …
ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface
S Uchikawa, M Yoda, T Tohmonda, A Kanaji… - Cytokine, 2015 - Elsevier
Abstract Interleukin (IL)-1 is one of the most evolutionarily conserved cytokines and plays an
essential role in the regulation of innate immunity. IL-1 binds to two different receptors, IL …
essential role in the regulation of innate immunity. IL-1 binds to two different receptors, IL …
ADAM17 at the interface between inflammation and autoimmunity
The discovery of the disintegrin and metalloproteinase 17 (ADAM17), originally identified as
tumor necrosis factor-a converting enzyme (TACE) for its ability as sheddase of TNF-α …
tumor necrosis factor-a converting enzyme (TACE) for its ability as sheddase of TNF-α …
The basis of complications in the context of SARS-CoV-2 infection: pathological activation of ADAM17
S Jiang, H Yang, Z Sun, Y Zhang, Y Li, J Li - Biochemical and Biophysical …, 2023 - Elsevier
The virulence of SARS-CoV-2 decreases with increasing infectivity, the primary approaches
for antiviral treatments will be preventing or minimizing the complications resulting from virus …
for antiviral treatments will be preventing or minimizing the complications resulting from virus …
The metalloprotease ADAM12 regulates the effector function of human Th17 cells
AX Zhou, A El Hed, F Mercer, L Kozhaya, D Unutmaz - PLoS One, 2013 - journals.plos.org
A key modulator of immune homeostasis, TGFβ has an important role in the differentiation of
regulatory T cells (Tregs) and IL-17-secreting T cells (Th17). How TGFβ regulates these …
regulatory T cells (Tregs) and IL-17-secreting T cells (Th17). How TGFβ regulates these …
[HTML][HTML] ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer
N Schumacher, S Rose-John - … et Biophysica Acta (BBA)-Molecular Cell …, 2022 - Elsevier
It was realized in the 1990s that some membrane proteins such as TNFα, both TNF
receptors, ligands of the EGF-R and the Interleukin-6 receptor are proteolytically cleaved …
receptors, ligands of the EGF-R and the Interleukin-6 receptor are proteolytically cleaved …
ADAM10-a “multitasker” in sepsis: Focus on its posttranslational target
S Liao, Y Lin, L Liu, S Yang, YY Lin, J He… - Inflammation Research, 2023 - Springer
Background Sepsis has a complex pathogenesis in which the uncontrolled systemic
inflammatory response triggered by infection leads to vascular barrier disruption …
inflammatory response triggered by infection leads to vascular barrier disruption …
The role of interleukin 6 during viral infections
L Velazquez-Salinas, A Verdugo-Rodriguez… - Frontiers in …, 2019 - frontiersin.org
Our recently published research on the characterization of vesicular stomatitis virus (VSV)
pathogenesis in swine, identified a systemic upregulation of interleukin 6 (IL-6) during the …
pathogenesis in swine, identified a systemic upregulation of interleukin 6 (IL-6) during the …